134518-89-1

Upstream product

• 3282-30-2 pivaloyl chloride 
• 100-83-4 meta-hydroxybenzaldehyde 
• 100-52-7 benzaldehyde 

Downstream Products

• 693818-54-1 4-(4-methoxyphenyl)-3-phenyl-4-(3-pivaloyloxyphenyl)but-1-ene 
• 879893-02-4 4-[4-(2-chloroethoxy)phenyl]-4-[3-(pivaloyloxy)phenyl]-3-phenylbut-1-ene 
• 134519-01-0 3-(dimethoxymethyl)phenyl pivalate 
• 1618079-27-8 methyl 2-(tert-butylamino)-5-(3-(pivaloyloxy)phenyl)-4-(thiophene-2-carbonyl)furan-3-carboxylate 
• 1618079-37-0 methyl 5-(tert-butylamino)-2-(3-(pivaloyloxy)phenyl)-4-(thiophene-2-carbonyl)furan-3-carboxylate 

Relevant academic research and scientific papers

Diastereoselective synthesis of 2-aryl-3-vinyl-2,3-dihydrobenzo[b]furans through a Sakurai reaction: A mechanistic proposal

The condensation of 2,3-dihydrobenzoxasilepins with aromatic aldehydes in the presence of boron trifluoride to form 2,3-dihydrobenzofurans shows a level of diastereoselection which is a function of the electronic nature of the aldehyde and the polarity of

Regioselective synthesis of 3,4,5-trisubstituted 2-aminofurans

Three series of methyl 5-substituted 2-aminofuran-4-keto-3-carboxylates have been prepared following a multicomponent reaction strategy by the addition of an isocyanide to 4-oxo-2-butynoate in the presence of an aldehyde. The cycloaddition regioselectivit

ETHER BENZYLIDENE PIPERIDINE 5-MEMBERED ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS

The present invention relates to compounds of the Formula (I), and pharmaceutically acceptable salts thereof, and their use in the treatment of FAAH-mediated diseases or condition.

ETHER BENZYLIDENE PIPERIDINE ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS

The present invention relates to compounds of Formula (I) wherein Ar is optionally substituted phenyl or 6-membered heteroaryl moiety, or a benzisoxazole, pyrrolopyridine, or benzotriazole group; or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions containing the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity, including pain, urinary incontinence, overactive bladder, emesis, cognitive disorders, anxiety, depression, sleeping disorders, eating disorders, movement disorders, glaucoma, psoriasis, multiple sclerosis, cerebrovascular disorders, brain injury, gastrointestinal disorders, hypertension, or cardiovascular disease.

4- [3- (ARYLOXY) BENZYLIDENE] -3-METHYL PIPERIDINE 5-MEMBERED ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS

The present invention relates to compounds of Formula (I), wherein Ar is a 5-membered heteroaryl moiety and X, Y and Z are independently N or CH; or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions containing the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity.

4- [3- (ARYLOXY) BENZYLIDENE] -3-METHYL PIPERIDINE ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS

The present invention relates to compounds of Formula (I), wherein Ar is optionally substituted phenyl or heteroaryl and X, Y and Z are independently N or CH; or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions containing the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity.

Comparison of convenient alternative synthetic approaches to 4-[(3-tert-butyldimethylsilyloxy)phenyl]-4-methoxyspiro[1,2-dioxetane-3, 2′-adamantane]

The preparation of 4-(3-tert-butyldimethylsilyloxyphenyl)-4-methoxyspiro[1, 2-dioxetane-3,2′-adamantane] by two different approaches is described and the results are compared with previously reported data. The precursor olefin, 1-[3-(tert-butyldimethylsilyloxy)phenyl]-1-methoxy-2-spiroadamantylidene is obtained from 3-hydroxybenzaldehyde by both Horner-Wadsworth-Emmons and McMurry coupling reactions in 42% overall yield in both cases. 1,2-Dioxetane preparation by singlet oxygen addition, obtained through calcium peroxide diperoxohydrate thermolysis, is compared with conventional photooxygenation. Georg Thieme Verlag Stuttgart.

The [2+2]-photocycloaddition of aromatic aldehydes and ketones to 3,4-dihydro-2-pyridones: Regioselectivity, diastereoselectivity, and reductive ring opening of the product oxetanes

3,4-Dihydro-2-pyridones [3,4-Dihydropyridin-2(1H)-ones] 6 were evaluated with respect to their use as alkene components in stereoselective Paterno-Buechi reactions. The parent compound 6a was shown to be a versatile synthetic building block that reacted w

Synthesis of stable water-soluble chemiluminescent 1,2-dioxetanes and intermediates therefor

A novel synthesis of compounds having the formula: STR1 wherein T is a stabilizing spiro-linked polycycloalkylidene group, R3 is a C1 -C20 alkyl, aralkyl or heteroatom containing group, Y is an aromatic fluorescent chromophore, and Z is a cleavable group which, when cleaved, induces decomposition of the dioxetane ring and emission of optically detectable light, is disclosed. A tertiary phosphorous acid alkyl ester of the formula: wherein R1 is a lower alkyl group, is reacted with an aryl dialkyl acetal produced by reacting a corresponding aryl aldehyde with an alcohol of the formula: wherein R3 is as defined above, to produce a 1-alkoxy-1-arylmethane phosphonate ester of the formula: STR2 reacting the phosphonate with base to produce a phosphonate-stabilized carbanion, reacting the carbanion with a ketone of the formula: wherein T is as defined above, to produce an enol ether of the formula: STR3 then oxygenating the double bond in the enol ether to give the corresponding 1,2-dioxetane compound.