87995-27-5Relevant academic research and scientific papers
Total synthesis of (+)-petromyroxol via tandem α-aminoxylation-allylation and asymmetric dihydroxylation-SN2 cyclization approach
Nookaraju,Kumar, Pradeep
, p. 63311 - 63317 (2015/08/06)
The total synthesis of (+)-petromyroxol, a tetrahydrofuran (THF)-diol fatty acid, isolated from sea lamprey larvae (Petromyzon marinus) is reported. The present synthesis employs a tandem α-aminoxylationallylation, cross metathesis and tandem asymmetric d
Fe(III)/NaBH4-mediated free radical hydrofluorination of unactivated alkenes
Barker, Timothy J.,Boger, Dale L.
supporting information; experimental part, p. 13588 - 13591 (2012/10/08)
A powerful Fe(III)/NaBH4-mediated free radical hydrofluorination of unactivated alkenes is disclosed using Selectfluor reagent as a source of fluorine and resulting in exclusive Markovnikov addition. In contrast to the traditional and unmanageable free radical hydrofluorination of alkenes, the Fe(III)/NaBH4-mediated reaction is conducted under exceptionally mild reaction conditions (0 °C, 5 min, CH3CN/H2O). The reaction can be conducted open to the air and with water as a cosolvent and demonstrates an outstanding substrate scope and functional group tolerance.
Targeting the heat shock protein 90 dimer with dimeric inhibitors
Kusuma, Bhaskar Reddy,Peterson, Laura B.,Zhao, Huiping,Vielhauer, George,Holzbeierlein, Jeffrey,Blagg, Brian S. J.
experimental part, p. 6234 - 6253 (2011/10/31)
The design, synthesis, and biological evaluation of conformationally constrained coumermycin A1 analogues are reported. Compounds were evaluated against both breast cancer (SKBr3 and MCF7) and prostate cancer (PC3 mm2, A549, and HT29) cell lines. Non-noviosylated coumermycin A1 analogues that manifest potent antiproliferative activity resulting from Hsp90 inhibition are provided, wherein replacement of the stereochemically complex noviose sugar with readily available piperidine rings resulted in ü100 fold increase in antiproliferative activities as compared to coumermycin A1, producing small molecule Hsp90 inhibitors that exhibit nanomolar activities.
O-Nitrophenyl sulfoxides: Efficient precursors for the mild preparation of alkenes
Lu, Xiao,Long, Timothy E.
supporting information; experimental part, p. 249 - 252 (2010/04/06)
(Chemical Equation Presented) o-Nitrophenyl sulfoxides were found to be efficient synthetic precursors of various alkene types. The elimination occurs in toluene and NaOAc to generate substituted and terminal alkenes. Alkene products were easily obtained in high purity due to the simultaneous precipitation of the o-nitrophenyl sulfenic acid byproduct. The methods described have practical applications for the preparation of unsaturated compounds under mild, thermolytic conditions. 2009 American Chemical Society.
Thienylalanine derivatives as inhibitors of cell adhesion
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, (2008/06/13)
The present invention relates to compounds of formula (I), in which A, B, X, Y, R1, R2, R3 and n have the meanings indicated in the claims. The compounds of formula (I) are valuable pharmacologically active compounds. They
CHEMOSELECTIVITY IN THE CONJUGATE ADDITION OF ALLYLSILANE TO MICHAEL ACCEPTORS
Majetich, George,Casares, Ada M.,Chapman, D.,Behnke, M.
, p. 1909 - 1912 (2007/10/02)
The allylic carbanion species generated by treatment of allylsilane with fluoride ion undergoes highly chemoselective conjugate addition to a series of Michael acceptors for which alternative known allylation procedures proved less general.
