68017-21-0

Upstream product

• 100-39-0 benzyl bromide 
• 3128-06-1 5-ketohexanoic acid 
• 186581-53-3 diazomethane 
• 67852-85-1 glutaric acid chloride monobenzyl ester 
• 108-55-4 glutaric anhydride, 
• 54322-10-0 glutaric acid monobenzyl ester 
• 100-51-6 benzyl alcohol 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 87995-27-5 benzyl hex-5-enoate 
• 2495-35-4 benzylacrylate 
• 67-64-1 acetone 
• 1120-72-5 2-Methylcyclopentanone 

Downstream Products

• 136103-80-5 Benzyl 6,6-difluoro-5-methyl-5-hexenoate 
• 1029126-16-6 6-bromo-5-oxo-hexanoic acid benzyl ester 
• 1029126-05-3 2-amino-4-(3-benzyloxycarbonyl-propyl)-imidazole-1-carboxylic acid tert-butyl ester 
• 1309767-12-1 tert-butyl 4-(3-((benzyloxy)carbonyl)propyl)-2-((di-tert-butoxycarbonyl)amino)-imidazole-1-carboxylate 
• 57711-61-2 Benzyl-3-acetoxypropionat 

Relevant academic research and scientific papers

Synthesis method of 4-acetyl butyrate compound

The invention discloses a synthetic method of a 4-acetyl butyrate compound, and relates to the technical field of chemical synthesis, and the synthetic method comprises the following steps: taking acetone as a reaction solvent and a reactant to react with an acrylate compound under the catalytic action of tetrahydropyrrole; and after the reaction is finished, carrying out post-treatment on the reaction liquid to prepare the 4-acetyl butyrate compound. The method has the advantages of simple reaction system, environment friendliness, cheap and easily available raw materials, simple post-treatment operation, and no need of column chromatography purification, and is beneficial for industrial production.

Metal-Free, Visible-Light-Induced Selective C?C Bond Cleavage of Cycloalkanones with Molecular Oxygen

A metal-free, visible-light-induced oxidative C?C bond cleavage of cycloketones with molecular oxygen is described. Cooperative Br?nsted-acid catalysis and photocatalysis enabled selective C?C bond cleavage of cycloketones to generate an array of γ-, δ- and ?-keto esters under very mild conditions. Mechanistic studies indicate that singlet molecular oxygen (1O2) is responsible for this transformation.

Palladium/Copper-catalyzed Oxidation of Aliphatic Terminal Alkenes to Aldehydes Assisted by p-Benzoquinone

The development of an anti-Markovnikov Wacker-type oxidation for simple aliphatic alkenes is a significant challenge. Herein, a variety of aldehydes can be selectively obtained from various unbiased aliphatic terminal alkenes using PdCl2(MeCN)2/CuCl in the presence of p-benzoquinone (BQ) under mild reaction conditions. Isomerization of the terminal alkene to the internal alkene was suppressed via slow addition of the starting material to the reaction mixture. In addition to the Pd catalyst, CuCl and BQ were essential in order to obtain the anti-Markovnikov product with high selectivity. Terminal alkenes bearing a halogen substituent afforded their corresponding aldehydes with high anti-Markovnikov selectivity. The halogen acts as a directing group in the reaction. DFT calculations indicate that a μ-chloro Pd(II)?Cu(I) bimetallic species with BQ coordinated to Cu is the catalytically active species in the case of a terminal alkene without a directing group.

Palladium-Catalyzed Aerobic Anti-Markovnikov Oxidation of Aliphatic Alkenes to Terminal Acetals

Terminal acetals were selectively synthesized from various unbiased aliphatic terminal alkenes and 1,2-, 1,3-, or 1,4-diols using a PdCl2(MeCN)2/CuCl catalyst system in the presence of p-toluquinone under 1 atm of O2 and mild reaction conditions. The slow addition of terminal alkenes suppressed the isomerization to internal alkenes successfully. Electron-deficient cyclic alkenes, such as p-toluquinone, were key additives to enhance the catalytic activity and the anti-Markovnikov selectivity. The halogen groups in the alkenes were found to operate as directing groups, suppressing isomerization and increasing the selectivity efficiently.

Inhibition of Acinetobacter baumannii biofilm formation on a methacrylate polymer containing a 2-aminoimidazole subunit

A polymeric composite containing a 2-aminoimidazole derivative was synthesized. It was found that this polymer was resistant to biofilm colonization by Acinetobacter baumannii, no leaching of the 2-aminoimidazole derivative was observed after 2 weeks of treatment with deionized water, and the resulting polymer was not hemolytic.

Halogenated olefins, processes for their preparation and their use as pesticides

This are described new halogenated olefines of general formula I STR1 in which X1, X2, X3, n and A have the meanings given in the description as well as processes for their preparation. The compounds can be used as pesticides especially against insects and acarids.