88017-51-0Relevant academic research and scientific papers
One-Pot Synthesis of α-Amino Nitrile Units through Alkylative Strecker Cyanation from Formamides
Yu, Bao,Bodinier, Florent,Saague-Tenefo, Maximiliene,Gerardo, Patrice,Ardisson, Janick,Lannou, Marie-Isabelle,Sorin, Geoffroy
, p. 3634 - 3640 (2021/07/22)
In this work, we describe the one-pot synthesis of α-amino nitrile units by the concomitant addition of alkyl (or aryl) Grignard reagents and TMS cyanide through alkylative Strecker cyanation from readily available formamides. The reaction is broad in sco
Fluorocyanation of enamines
Dilman, Alexander D.,Belyakov, Pavel A.,Struchkova, Marina I.,Arkhipov, Dmitry E.,Korlyukov, Alexander A.,Tartakovsky, Vladimir A.
supporting information; experimental part, p. 5367 - 5370 (2010/10/21)
(Figure presented) A method for the fluorocyanation of enamines has been described. The reaction involves fluorination of the electron rich double bond with N-F reagent (Selectfluor or NFSI) accompanied by trapping of β-fluoroiminium cationic intermediate with cyanide nucleophile.
