88023-76-1Relevant academic research and scientific papers
Water Mediated Direct Thioamidation of Aldehydes at Room Temperature
Gupta, Ankush,Vankar, Jigarkumar K.,Jadav, Jaydeepbhai P.,Gururaja, Guddeangadi N.
, p. 2410 - 2420 (2022/02/23)
A mild, greener approach toward thioamide synthesis has been developed. Its unique features include water-mediated reaction with no input energy, additives, or catalysts as well. The presented protocol is attractive with readily available starting materials and the use of different array amines, along with a scaled-up method. Biologically active molecules such as thionicotinamide and thioisonicotinamide can be synthesized from this procedure.
K2S2O8-promoted aryl thioamides synthesis from aryl aldehydes using thiourea as the sulfur source
Bian, Yongjun,Qu, Xingyu,Chen, Yongqiang,Li, Jun,Liu, Leng
, (2018/09/10)
Thiourea as a sulfur atom transfer reagent was applied for the synthesis of aryl thioamides through a three-component coupling reaction with aryl aldehydes and N,N-dimethylformamide (DMF) or N,N-dimethylacetamide (DMAC). The reaction could tolerate various functional groups and gave moderate to good yields of desired products under the transition-metal-free condition.
Copper-Catalyzed Synthesis of Aryl Thioamides from Aryl Aldehydes and Tetramethylthiuram Disulfide
Zeng, Meng-Tian,Wang, Min,Peng, Han-Ying,Cheng, Yu,Dong, Zhi-Bing
, p. 644 - 650 (2018/01/27)
A novel and convenient method for the synthesis of aryl thioamides from aryl aldehydes and tetramethylthiuram disulfide (TMTD) without the use of sulfurating reagent was explored. In the presence of CuI and di- tert -butyl peroxide (DTBP), various aryl thioamides were prepared with good to excellent yields, tetramethylthiuram disulfide as thioamide source is essential for this transformation. The protocol features broad substrate scope, nice yields, operability and commercially available and inexpensive raw materials, showing its practical synthetic value in organic synthesis.
Aqueous Compatible Protocol to Both Alkyl and Aryl Thioamide Synthesis
Wei, Jianpeng,Li, Yiming,Jiang, Xuefeng
supporting information, p. 340 - 343 (2016/02/03)
An efficient aqueous synthesis of thioamides through aldehydes, sodium sulfide, and N-substituted formamides has been developed. Both alkyl and aryl aldehydes are amenable to this protocol. N-Substituted formamides are essential for this transformation. Readily available inorganic salt (sodium sulfide) serves as the sulfur source in water, which makes this method much more practical and efficient. Furthermore, the late-stage modification of bioactive molecules and derivatives through this protocol has been established.
Thiocarbamoylation of amine-containing compounds 6. Reactions of tetramethylthiuram disulfide with hydrazones of aromatic aldehydes
Boi, Luu Van,Floria, V.
, p. 344 - 347 (2007/10/03)
Thiocarbamoylation of hydrazones of aromatic aldehydes with tetramethylthiuram disulfide (TMTD) afforded diarylaldazines, 4,4-dimethylthiosemicarbazide, and 5-dimethylamino-l,3,4-thiadiazole-2-thiol. In addition, the reaction of TMTD with salicylaldehyde
