88057-00-5

Basic information

• Product Name: (2R,6S)-1-[(1R)-2-hydroxy-1-phenylethyl]-2-methyl-6-propylpiperidine
• Synonyms: (2R,6S)-1-[(1R)-2-hydroxy-1-phenylethyl]-2-methyl-6-propylpiperidine
• CAS NO: 88057-00-5
• Molecular Weight: 261.407
• Mol File: 88057-00-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2R,6S)-1-[(1R)-2-hydroxy-1-phenylethyl]-2-methyl-6-propylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,6S)-1-[(1R)-2-hydroxy-1-phenylethyl]-2-methyl-6-propylpiperidine(88057-00-5)
• EPA Substance Registry System: (2R,6S)-1-[(1R)-2-hydroxy-1-phenylethyl]-2-methyl-6-propylpiperidine(88057-00-5)

Safety Data

• Hazardous Substances Data: 88057-00-5(Hazardous Substances Data)

Upstream product

• 88056-94-4 (3R,5S)-3-Phenyl-5-propyl-hexahydro-oxazolo[3,2-a]pyridine-5-carbonitrile 
• 88056-92-2 (-)-2-cyano-6-phenyloxazolopiperidine 
• 917-64-6 methyl magnesium iodide 
• 88056-98-8 (3R,5S)-5-n-propyl-3-phenyl-2,3,5,6,7,8-hexahydro-oxazolo[3,2-a]pyridine 
• 56613-80-0 D-2-phenylglycinol 
• 177981-20-3 (6R)-1-[(1R)-2-hydroxy-1-phenylethyl]-6-methyl-2-piperidone 
• 152615-80-0 (3R,8aS)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo<3,2-a>pyridine 
• 927-77-5 n-propylmagnesium bromide 
• 204845-25-0 (3R,5R)-5-methyl-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 

Relevant articles and documents

Enantioselective synthesis of piperidine, indolizidine, and quinolizidine alkaloids from a phenylglycinol-derived δ-lactam

Starting from a common lactam, (3R,8aS)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine (1), or its enantiomer, the enantioselective synthesis of 2-alkylpiperidines and cis- and trans-2,6-dialkylpiperidines is reported. The potential of this approach is illustrated by the synthesis of the piperidine alkaloids (R)-coniine, (2R,6S)-dihydropinidine, (2R,6R)-lupetidine, and (2R,6R)-solenopsin A, the indolizidine alkaloids (5R,8aR)-indolizidine 167B and (3R,5S,8aS)-monomorine I, and the nonnatural base (4R,9aS)-4-methylquinolizidine.

Chiral 1,4-dihydropyridine equivalents: A new approach to the asymmetric synthesis of alkaloids. The enantiospecific synthesis of (+)- and (-)-coniine and -dihydropinidine

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