88071-95-8Relevant academic research and scientific papers
Cyclic peptides as selective substrates and suicide substrate precursors of trypsin-like proteinases
Bogetto, Nicole,Vilain, Anne-Cecile,Montagne, Jean-Jacques,Reboud-Ravaux, Michele,Mazaleyrat, Jean-Paul,et al.
, p. 152 - 166 (2007/10/02)
Cyclopeptides of general formula c1-aB(CH2X)-Gly4>, in which P1 is arginine or lysine and aB(CH2X) an ortho- or meta-aminobenzoic acid residue substituted in the para position to the nitrogen atom by a methyl (X=H), a phenoxymethyl
Substituted N-arylazetidinones, β-lactamases potential inhibitors
Zrihen,Labia,Wakselman
, p. 307 - 314 (2007/10/02)
Two classes of substituted N-aryl azetidinones have been prepared by cyclization of various β-bromopropionanilides. The 7a class possess a carboxylic function in ortho, meta or para of the nitrogen and possibly another alkyl substituent on the aromatic nucleus. In the 7a class, the aromatic nucleus is substituted by a bromomethyl group instead of the alkyl one. Few of these azetidinones show a good affinity for various cell-free β-lactamases preparations, and thus are pretty good competitive inhibitors. Nevertheless, they do not act synergistically with ampicillin on β-lactamase producing bacterial strains. A poor antibacterial activity has been detected for few compounds. The azetidinones 7b which possess a latent electrophilic quinonimine methide function, do not give any progressive (suicide type) inhibition, or inactivation, of the enzymatic activity.
