880763-29-1

Upstream product

• 1037293-71-2 3-benzyloxy-4-oxo-4H-pyran-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 4097-89-6 2,2',2''-triaminotriethylamine 
• 100-44-7 benzyl chloride 
• 500371-01-7 3-(benzyloxy)-4-oxo-4H-pyran-2-carbaldehyde 
• 119736-16-2 3-(benzyloxy)-1-((tert-butoxycarbonyl)amino)-4-oxo-1,4-dihydropyridine-2-carboxylic acid ethyl ester 
• 61049-69-2 3-O-benzylmaltol 
• 118-71-8 Maltol 
• 100-39-0 benzyl bromide 

Downstream Products

• 1402887-82-4 N,N',N''-(nitrilotris(ethane-2,1-diyl))tris(3-(benzyloxy)-4-oxo-1,4-dihydropyridine-2-carboxamide) 
• 1402887-83-5 N,N',N''-(nitrilotris(ethane-2,1-diyl))tris(3-(benzyloxy)-1-methyl-4-oxo-1,4-dihydropyridine-2-carboxamide) 
• 1402887-84-6 N,N',N''-(nitrilotris(ethane-2,1-diyl))tris(3-(benzyloxy)-1-ethyl-4-oxo-1,4-dihydropyridine-2-carboxamide) 
• 1402887-85-7 N,N',N''-(nitrilotris(ethane-2,1-diyl))tris(3-(benzyloxy)-1-butyl-4-oxo-1,4-dihydropyridine-2-carboxamide) 
• 1402887-86-8 N,N',N''-(nitrilotris(ethane-2,1-diyl))tris(3-(benzyloxy)-1-hexyl-4-oxo-1,4-dihydropyridine-2-carboxamide) 
• 1037293-86-9 N,N',N''-(nitrilotris(ethane-2,1-diyl))tris(3-(benzyloxy)-1-(2-hydroxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxamide) 
• 1037293-89-2 N,N',N''-(nitrilotris(ethane-2,1-diyl))tris(3-(benzyloxy)-1-(2-(2-hydroxyethoxy)ethyl)-4-oxo-1,4-dihydropyridine-2-carboxamide) 
• 1402887-87-9 N,N',N''-(nitrilotris(ethane-2,1-diyl))tris(3-(benzyloxy)-1-(2-(2-hydroxyethylamino)ethyl)-4-oxo-1,4-dihydropyridine-2-carboxamide) 
• 1037293-72-3 N,N',N''-(nitrilotris(ethane-2,1-diyl))tris(3-(benzyloxy)-1-(2-methoxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxamide) 

Relevant academic research and scientific papers

Synthesis, physico-chemical properties, and antimicrobial evaluation of a new series of iron(III) hexadentate chelators

A series of related 3-hydroxypyridin-4-one hexadentate ligands have been synthesized. These chelators were found to possess a high affinity for iron(III), with a pFe value of about 30. As iron is a critical element to the survival of bacteria, these chelators were predicted to inhibit the growth of bacteria by disrupting bacterial iron absorption. Indeed, they were demonstrated to possess appreciable inhibitory activity against both Gram-positive and Gram-negative bacteria, and therefore, they have potential as antimicrobial agents. 1c and 1g were found to be particularly effective against Gram-negative species. Graphical Abstract: A series of related 3-hydroxypyridin-4-one hexadentate ligands have been synthesized. These chelators were found to possess a high affinity for iron(III), and exhibit appreciable inhibitory activity against both Gram-positive and Gram-negative bacteria, and therefore, they have potential as antimicrobial agents. [Figure not available: see fulltext.]

CHELATING AGENTS

The present invention relates to chelating agents, in particular to chelating agents which are capable of forming complexes with paramagnetic metal ions such as iron (III) and gadolinium (III). The invention also relates to the complexes formed and their

MULTIDENTATE PYRONE-DERIVED CHELATORS FOR MEDICINAL IMAGING AND CHELATION

Provided herein are chelating agents and metal chelates that are useful in diagnostic and therapeutic applications. The uses of metal chelates provided herein include their use as contrast agents in medical imaging modalities, such as magnetic resonance imaging (MRI).

Tris(pyrone) chelates of Gd(III) as high solubility MRI-CA

Two tripodal, hexadentate pyrone-based chelators have been prepared. These ligands form stable, soluble complexes with gadolinium(III). The complexes show aqueous stability comparable to that of [Gd(DTPA)]2- at pH 7.4. Evaluation by relaxometry shows that these complexes have two inner-sphere water molecules and a very fast water exchange rate. The solution behavior of these complexes suggests that they may be attractive as high relaxivity, next-generation magnetic resonance imaging contrast agents. Copyright