880767-53-3

Upstream product

• 75-36-5 acetyl chloride 
• 86286-50-2 (4R,5S)-4,5-diphenyl-1,3-oxazolidin-2-one 

Downstream Products

• 220998-02-7 (R)-3-(3-benzyloxymethyl-2-methoxypyridin-4-yl)-3-hydroxypentanoic acid 
• 284684-24-8 (S)-3-(3-benzyloxymethyl-2-methoxypyridin-4-yl)-3-hydroxypentanoic acid 

Relevant academic research and scientific papers

Practical formal total syntheses of the homocamptothecin derivative and anticancer agent diflomotecan via asymmetric acetate aldol additions to pyridine ketone substrates

(Chemical Equation Presented) Two practical, efficient, and scalable asymmetric routes to DE ring fragment 7, a key building block in the synthesis of the homocamptothecin derivative diflomotecan 4, are described. The "acetal route" starts from 2-chloro-4

NOVEL PROCESSES FOR THE PRODUCTION OF USEFUL INTERMEDIATES

The present application relates to a new process for the asymmetric production of 3-(pyridin-4-yl)-3-hydroxy-pentanoic acid derivatives, which are useful intermediates in the manufacture of compounds that are known to show antiproliferative activity.