284684-24-8

Upstream product

• 186668-50-8 1-{3-[(benzyloxy)methyl]-2-methoxy-4-pyridinyl}-1-propanone 
• 880767-53-3 (4R,5S)-3-acetyl-4,5-diphenyloxazolidin-2-one 
• 913831-72-8 (4S,5R)-3-acetyl-4,5-diphenyloxazolidin-2-one 
• 186668-51-9 tert-butyl 3-{3-[(benzyloxy)methyl]-2-methoxy-4-pyridinyl}-3-hydroxypentanoate 
• 880767-52-2 3-benzyloxymethyl-4-(2-ethyl[1,3]dioxolan-2-yl)-2-methoxypyridine 
• 219832-72-1 4(2-ethyl-1,3-dioxan-2-yl)-3-hydroxymethyl-2-methyoxypyridine 
• 880767-51-1 4-(2-ethyl[1,3]dioxolan-2-yl)-2-methoxypyridine-3-carbaldehyde 
• 219832-71-0 4-(2-ethyl[1,3]dioxolan-2-yl)-2-methoxypyridine 
• 87121-53-7 1-(2-chloropyridin-4-yl)propan-1-one 
• 72716-86-0 4-cyano-2-methoxypyridine 
• 33252-30-1 2-chloro-4-pyridinenitrile 
• 880767-50-0 1-(2-methoxypyridin-4-yl)propan-1-one 
• 220998-01-6 3-(3-benzyloxymethyl-2-methoxy-pyridin-4-yl)-3-hydroxy-pentanoic acid 

Downstream Products

• 387862-46-6 (S)-5-Ethyl-5-hydroxy-2,5,6,9-tetrahydro-8-oxa-2-aza-benzocycloheptene-1,7-dione 

Relevant academic research and scientific papers

Practical formal total syntheses of the homocamptothecin derivative and anticancer agent diflomotecan via asymmetric acetate aldol additions to pyridine ketone substrates

(Chemical Equation Presented) Two practical, efficient, and scalable asymmetric routes to DE ring fragment 7, a key building block in the synthesis of the homocamptothecin derivative diflomotecan 4, are described. The "acetal route" starts from 2-chloro-4

NOVEL PROCESSES FOR THE PRODUCTION OF USEFUL INTERMEDIATES

The present application relates to a new process for the asymmetric production of 3-(pyridin-4-yl)-3-hydroxy-pentanoic acid derivatives, which are useful intermediates in the manufacture of compounds that are known to show antiproliferative activity.

Comptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues

The compound of the formula wherein the substituents are defined as in the specification and its non-toxic, pharmaceutically acceptable salts which are useful for the treatment of viral infections, parasitic diseases and the treatment of cancer.

Topoisomerase I-mediated antiproliferative activity of enantiomerically pure fluorinated homocamptothecins

Homocamptothecin (hCPT) is an E-ring modified camptothecin (CPT) analogue bearing a methylene spacer between the alcohol and carboxyl functions of the CPT lactone. Combining pronounced inhibitory activity of topoisomerase I (Topo I) with enhanced plasma s