88082-66-0

Basic information

• Product Name: (1R,2R)-2-AMINO-1,2-DIPHENYLETHANOL, 97
• Synonyms: (1R,2R)-2-AMINO-1,2-DIPHENYLETHANOL, 97;(R,R)-(+)-2-Amino-1,2-diphenylethanol;(R,R)-(+)-2-Amino-1,2-diphenylethanol >=99.5% (HPLC);(1R,2R)-2-amino-1,2-diphenylethan-1-ol;(1R,2R)-2-amino-1,2-diphenylethanol(WX180059)
• CAS NO: 88082-66-0
• Molecular Formula: C₁₄H₁₅NO
• Molecular Weight: 213.275
• Product Categories: Amino Alcohols;Chiral Building Blocks;Organic Building Blocks
• Mol File: 88082-66-0.mol
• Article Data: 44

Chemical Properties

• Melting Point: 143-147 °C(lit.)
• Boiling Point: 374.3 °C at 760 mmHg
• Flash Point: 180.2 °C
• Appearance: /
• Density: 1.148 g/cm³
• Storage Temp.: 2-8°C
• PKA: 11.70±0.45(Predicted)
• BRN: 1212829
• CAS DataBase Reference: (1R,2R)-2-AMINO-1,2-DIPHENYLETHANOL, 97(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-2-AMINO-1,2-DIPHENYLETHANOL, 97(88082-66-0)
• EPA Substance Registry System: (1R,2R)-2-AMINO-1,2-DIPHENYLETHANOL, 97(88082-66-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 88082-66-0(Hazardous Substances Data)

Usage

General Description

(1R,2R)-2-AMINO-1,2-DIPHENYLETHANOL, 97 is a chemical compound that consists of a chiral center and two phenyl groups. It is a white to off-white crystalline solid with a purity of 97%. (1R,2R)-2-AMINO-1,2-DIPHENYLETHANOL, 97 is commonly used in the synthesis of pharmaceuticals and other organic compounds. It is known for its ability to act as a chiral ligand in asymmetric catalysis and as a chiral auxiliary in a variety of chemical reactions. Additionally, (1R,2R)-2-AMINO-1,2-DIPHENYLETHANOL, 97 may also have potential applications in the development of new drug molecules and as a building block in organic synthesis.

Upstream product

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Downstream Products

• 92552-75-5 4,5-diphenyl-2-oxazolidinone 
• 6275-45-2 dichloro-acetic acid-(α'-hydroxy-bibenzyl-α-ylamide) 
• 530-36-9 (1R,2R)-2-amino-1,2-diphenylethane-1-ol 
• 492-70-6 1,2-diphenyl-1,2-ethanediol 
• 530-36-9 (1S,2S)-2-amino-1,2-diphenylethanol 
• 530-36-9 2-amino-1,2-diphenylethanol 
• 49855-40-5 L_g-threo-α'-chloro-bibenzyl-α-ylamine 
• 6287-74-7 (+/-)-erythro-α'-(2-diethylamino-ethylamino)-bibenzyl-α-ol 
• 23364-44-5 (1S,2R)-2-Amino-1,2-diphenylethanol 
• 23190-16-1 (1R,2S)-2-Amino-1,2-diphenylethanol 
• 530-36-9 threo-1,2-diphenyl-2-aminoethan-1-ol 
• 49855-40-5 (+/-)-erythro-α'-chloro-bibenzylyl-(α)-amine 
• 49855-40-5 (+/-)-threo-α'-chloro-bibenzylyl-(α)-amine 
• 780-25-6 N-benzylidene benzylamine 

Relevant articles and documents

Site-Specific C(sp3)–H Aminations of Imidates and Amidines Enabled by Covalently Tethered Distonic Radical Anions

The utilization of N-centered radicals to synthesize nitrogen-containing compounds has attracted considerable attention recently, due to their powerful reactivities and the concomitant construction of C?N bonds. However, the generation and control of N-centered radicals remain particularly challenging. We report a tethering strategy using SOMO-HOMO-converted distonic radical anions for the site-specific aminations of imidates and amidines with aid of the non-covalent interaction. This reaction features a remarkably broad substrate scope and also enables the late-stage functionalization of bioactive molecules. Furthermore, the reaction mechanism is thoroughly investigated through kinetic studies, Raman spectroscopy, electron paramagnetic resonance spectroscopy, and density functional theory calculations, revealing that the aminations likely involve direct homolytic cleavage of N?H bonds and subsequently controllable 1,5 or 1,6 hydrogen atom transfer.

Large-scale preparation of key building blocks for the manufacture of fully synthetic macrolide antibiotics

Key building blocks for the production of fully synthetic macrolides have been scaled-up in first time pilot plant and kilo-lab campaigns. These building blocks have supported the discovery of new macrolide antibiotics as well as ongoing preclinical studies.

HETEROARYL ACID MORPHOLINONE COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER

The present invention provides MDM2 inhibitor compounds of Formula (I), or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor of Formula (I).