881298-23-3Relevant academic research and scientific papers
Copper(I) iodide catalyzed domino process to quinazolin-4(3H)-ones
Zhou, Jing,Fu, Liangbing,Lv, Man,Liu, Jinsong,Pei, Duanqing,Ding, Ke
, p. 3974 - 3980 (2008)
An efficient synthesis of substituted quinazolin-4(3H)-ones by a one-pot ligand-free CuI-catalyzed coupling/condensative cyclization under mild conditions is described. Our study provides an alternative strategy for the preparation of biologically active quinazolin-4(3H)-ones. Georg Thieme Verlag Stuttgart.
Pd/C as an efficient heterogeneous catalyst for carbonylative four-component synthesis of 4(3H)-quinazolinones
Natte, Kishore,Neumann, Helfried,Wu, Xiao-Feng
, p. 4474 - 4480 (2015/09/01)
Quinazolinones are of interest in the fields of pharmaceuticals and medicinal chemistry. The application of palladium on activated charcoal (Pd/C) as a heterogeneous catalyst was investigated for the carbonylation of 2-iodoanilines with trimethyl orthofor
Ammonium chloride-catalyzed one-pot synthesis of 4(3H)-quinazolinones under solvent-free conditions
Huang, Guoli,Liu, Bo,Teng, Mingyu,Chen, Yegao
supporting information, p. 1786 - 1794 (2014/06/09)
Ammonium chloride, which is a very inexpensive and readily available reagent, can efficiently catalyze three-component, one-pot condensation reactions of 2-amino-benzoic acid esters, ortho esters, and aromatic amines to afford the corresponding 4(3H)-quinazolinones in good to excellent yields under solvent-free conditions.
An efficient, greener, and solvent-free one-pot multicomponent synthesis of 3-substituted quinazolin-4(3H)ones and thienopyrimidin-4(3H)ones
Jalani, Hitesh B.,Pandya, Amit N.,Pandya, Dhaivat H.,Sharma, Jayesh A.,Sudarsanam,Vasu, Kamala K.
, p. 4062 - 4064 (2012/08/28)
Herein, we report an efficient, greener, and solvent-free novel method for the synthesis of 3-substituted quinazolin-4(3H)ones and thienopyrimidin-4(3H) ones in a one-pot sequence using methyl anthranilate or 2-aminothiophene-3- carboxylate with N,N′-dimethyl formamide dimethyl acetal and various anilines. The driving force for this reaction is the removal of N,N′-dimethylamine by various anilines resulting in 3-substituted quinazolin-4(3H)ones and thienopyrimidin-4(3H)ones.
