881812-73-3Relevant academic research and scientific papers
Advantage of in situ generation of N-arylsulfonyl imines from α-amide sulfones in the phase-transfer-catalyzed asymmetric Strecker reaction
Ooi, Takashi,Uematsu, Yukitaka,Fujimoto, Jun,Fukumoto, Kazuhiro,Maruoka, Keiji
, p. 1337 - 1340 (2007/10/03)
Highly efficient, catalytic enantioselective synthesis of N-arylsulfonyl α-amino nitriles from the corresponding α-amido sulfones has been achieved under toluene-aqueous potassium cyanide biphasic conditions using chiral quaternary ammonium iodide (R,R,R)-1 as an effective phase-transfer catalyst. This Strecker synthesis involving the in situ generation of the reactive N-sulfonyl imines is advantageous for the cyanation of the substrates having primary and secondary alkyl substituents.
Asymmetric Strecker reaction of aldimines using aqueous potassium cyanide by phase-transfer catalysis of chiral quaternary ammonium salts with a tetranaphthyl backbone
Ooi, Takashi,Uematsu, Yukitaka,Maruoka, Keiji
, p. 2548 - 2549 (2007/10/03)
The phase-transfer-catalyzed, highly enantioselective cyanation of aldimines using aqueous KCN has been realized based on the molecular design of chiral quaternary ammonium iodide 2c bearing a stereochemically defined tetranaphthyl backbone. For example,
