881902-44-9

Upstream product

• 30988-17-1 methyl 2-isocyanatoacetate 
• 64-19-7 acetic acid 
• 882004-10-6 (S)-tert-butyl 3-cyclopropyl-1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate 
• 881902-41-6 [(1S,2S)-1-Cyclohexyl-3-(cyclopropylmethyl-amino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester 
• 89483-06-7 (2S)-2-[[(tert-butoxy)carbonyl]amino]-3-cyclopropylpropanoic acid 
• 107202-57-3 ((S)-Cyclohexyl-(R)-oxiranyl-methyl)-carbamic acid tert-butyl ester 
• 881902-43-8 ((1S,2S)-1-Cyclohexyl-3-{3-[(S)-2-cyclopropyl-1-(methoxy-methyl-carbamoyl)-ethyl]-1-cyclopropylmethyl-ureido}-2-hydroxy-propyl)-carbamic acid tert-butyl ester 

Downstream Products

• 881902-45-0 (4S,5S)-5-{3-[(S)-2-({[((S)-tert-Butoxycarbonyl-phenyl-methyl)-carbamoyl]-methyl}-carbamoyl)-1-cyclopropylmethyl-2-hydroxy-ethyl]-1-cyclopropylmethyl-ureidomethyl}-4-cyclohexyl-2,2-dimethyl-oxazolidine-3-carboxylic acid isobutyl ester 
• 905928-76-9 (4S,5S)-5-{3-[2-({[((S)-tert-Butoxycarbonyl-phenyl-methyl)-carbamoyl]-methyl}-carbamoyl)-1-cyclopropylmethyl-2-oxo-ethyl]-1-cyclopropylmethyl-ureidomethyl}-4-cyclohexyl-2,2-dimethyl-oxazolidine-3-carboxylic acid isobutyl ester 
• 881902-46-1 (S)-(2-{3-[3-((S)-3-Cyclohexyl-3-isobutoxycarbonylamino-2-oxo-propyl)-3-cyclopropylmethyl-ureido]-4-cyclopropyl-2-oxo-butyrylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester 
• 905927-78-8 {(S)-2-Acetoxy-3-[3-((2S,3S)-3-cyclohexyl-2-hydroxy-3-isobutoxycarbonylamino-propyl)-3-cyclopropylmethyl-ureido]-4-cyclopropyl-butyrylamino}-acetic acid methyl ester 
• 905930-08-7 (4S,5S)-5-{3-[(S)-2-(Carboxymethyl-carbamoyl)-1-cyclopropylmethyl-2-hydroxy-ethyl]-1-cyclopropylmethyl-ureidomethyl}-4-cyclohexyl-2,2-dimethyl-oxazolidine-3-carboxylic acid isobutyl ester 
• 905927-76-6 {(S)-2-Acetoxy-3-[3-((2S,3S)-3-amino-3-cyclohexyl-2-hydroxy-propyl)-3-cyclopropylmethyl-ureido]-4-cyclopropyl-butyrylamino}-acetic acid methyl ester 

Relevant academic research and scientific papers

Depeptidization efforts on P3-P′2 α-ketoamide inhibitors of HCV NS3-4A serine protease: Effect on HCV replicon activity

Depeptidization efforts of the P3-P2 region of P 3 capped α-ketoamide inhibitor of HCV NS3 serine protease 1 are reported. We clearly established that N-methylation of the P2 nitrogen and modification of the P2′