882004-93-5Relevant academic research and scientific papers
Kilogram synthesis of a LFA-1/ICAM inhibitor
Delmonte, Albert J.,Waltermire, Robert E.,Fan, Yu,McLeod, Douglas D.,Gao, Zhinong,Gesenberg, Kirsten D.,Girard, Kevin P.,Rosingana, Miguel,Wang, Xuebao,Kuehne-Willmore, Jennifer,Braem, Alan D.,Castoro, John A.
, p. 553 - 561 (2011/07/30)
The process development and the kilogram-scale synthesis of BMS-587101 (1) are described. The synthesis features a [3 + 2] azomethine ylide cycloaddition to efficiently build the spirocyclic core in a diastereoselective fashion followed by a classical res
Crystalline forms and process for preparing spiro-hydantoin compounds
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Page/Page column 35-36, (2010/10/20)
A process is provided for preparing spiro-hydantoin compounds of the formula II wherein Z is N or CR4b; K and L are independently O or S; Ar is an optionally substituted aryl or heteroaryl; A2 is a linker, G′ is a linker; Q is a link
