88203-16-1Relevant academic research and scientific papers
Sonogashira cross-coupling reaction in 4-chloro-2- trichloromethylquinazoline series is possible despite a side dimerization reaction
Kieffer, Charline,Verhaeghe, Pierre,Primas, Nicolas,Castera-Ducros, Caroline,Gellis, Armand,Rosas, Roselyne,Rault, Sylvain,Rathelot, Pascal,Vanelle, Patrice
, p. 2987 - 2995 (2013/03/29)
We studied the Sonogashira coupling reaction between 4-chloro-2- trichloromethylquinazoline and various terminal alkynes, mainly in phenylacetylene series. A brief review of the literature shows that mono- or polybromo/chloromethylated substrates, especia
Reaction of Nitriles under Acidic Conditions. Part VI. Synthesis of Condensed 4-Chloro- and 4-Aminopyrimidines from ortho-Aminonitriles
Shishoo, C. J.,Devani, M. B.,Bhadti, V. S,Jain, K. S.,Ananthan, S.
, p. 119 - 126 (2007/10/02)
Condensation of a nitrile with benzene, furan and thiophene ortho-aminonitriles in the presence of dry hydrogen chloride yields condensed 4-chloropyrimidines, condensed 4-aminopyrimidines or a mixture of the two condensed pyrimidines in varying proportions depending upon the nature of the nitrile and the substrate, ortho-aminonitrile.
REACTION OF NITRILES UNDER ACIDIC CONDITIONS: A NOVEL, DIRECT FORMATION OF CONDENSED 4-CHLOROPYRIMIDINES
Shishoo, C. J.,Devani, M. B.,Bhadti, V. S.,Anathan, S.,Ullas, G. V.
, p. 4611 - 4612 (2007/10/02)
An unusual formation of condensed 4-chloropyrimidines in the reaction of o-aminonitriles with halogenoacetonitriles in the presence of dry hydrogen chloride gas is described.
