882175-64-6

Upstream product

• 3413-44-3 (R)-2-cyclohexen-1-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 61426-49-1 (1R)-2-bromocyclohex-2-en-1-ol 
• 50870-61-6 2-bromocyclohex-2-en-1-one 
• 882175-60-2 (S)-2-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-(4-methoxy-benzyloxyamino)-propan-1-ol 
• 882175-57-7 (3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-((E)-3-triethylsilanyloxy-propenyloxy)-cyclohexene 
• 882175-58-8 (R)-2-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-triethylsilanyloxy-propionaldehyde 
• 882175-71-5 (E)-3-[(1R,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyloxy]-acrylic acid methyl ester 
• 882175-55-5 (E)-3-[(1R,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyloxy]-prop-2-en-1-ol 
• 882175-53-3 (1α,2α,6α)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7-oxa-bicyclo[4.1.0]heptane 
• 882175-54-4 (1R,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enol 
• 882175-52-2 tert-butyl-(cyclohex-2-enyloxy)-dimethyl-silane 
• 882175-61-3 N-{2-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-hydroxy-propyl}-N-(4-methoxy-benzyloxy)-malonamic acid ethyl ester 

Relevant academic research and scientific papers

An enantiocontrolled approach for the synthesis of chiral 3,5-disubstituted 2(1H)-pyridinones

An enantioselective route for the convergent synthesis of chiral, nonracemic 5-substituted 3-acyl-2(1H)-pyridinones is reported. Claisen rearrangement provides direct access to the α-branched 2-[4-(tert-butyldimethylsilanoxy)cyclohex-2-enyl]-3-hydroxypropionaldehyde as a key intermediate. The application of mild oxidation conditions facilitates the preparation of a series of 3,5-disubstituted 2(1H)-pyridinones.