882494-54-4

Basic information

• Product Name: methyl 2-(2,6-dimethylphenylamino)-2-oxoacetate
• Synonyms: methyl 2-(2,6-dimethylphenylamino)-2-oxoacetate
• CAS NO: 882494-54-4
• Molecular Formula: C11H13NO3
• Molecular Weight: 207.22582
• Mol File: 882494-54-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: methyl 2-(2,6-dimethylphenylamino)-2-oxoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(2,6-dimethylphenylamino)-2-oxoacetate(882494-54-4)
• EPA Substance Registry System: methyl 2-(2,6-dimethylphenylamino)-2-oxoacetate(882494-54-4)

Safety Data

• Hazardous Substances Data: 882494-54-4(Hazardous Substances Data)

Upstream product

• 5781-53-3 monomethyl oxalyl chloride 
• 87-62-7 2,6-dimethylaniline 
• 5704-66-5 pyruvoyl chloride 
• 67-56-1 methanol 
• 52793-02-9 N-(2,6-dimethylphenyl)-3-oxobutanamide 

Relevant articles and documents

Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters

We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale.

Copper-Catalysed (Diacetoxyiodo)benzene-Promoted Aerobic Esterification Reaction: Synthesis of Oxamates from Acetoacetamides

A copper-catalysed (diacetoxyiodo)benzene-promoted aerobic esterification reaction of acetoacetamides was developed for the synthesis of oxamates, which are useful precursors in synthetic organic chemistry. This practical and mild synthetic approach proceeded at 25 °C under open-air conditions and afforded methyl 2-oxo-2-(phenylamino)acetates in good to excellent yields combined with C?C σ-bond cleavage and formal oxidative C?H bond functionalization. A mechanism is proposed. (Figure presented.).

Assembly of Primary (Hetero)Arylamines via CuI/Oxalic Diamide-Catalyzed Coupling of Aryl Chlorides and Ammonia

A general and practical catalytic system for aryl amination of aryl chlorides with aqueous or gaseous ammonia has been developed, with CuI as the catalyst and bisaryl oxalic diamides as the ligands. The reaction proceeds at 105-120°C to provide a diverse set of primary (hetero)aryl amines in high yields with various functional groups.