882511-65-1

Basic information

• Product Name: [6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(4-iodo-phenyl)-amine
• Synonyms: [6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(4-iodo-phenyl)-amine
• CAS NO: 882511-65-1
• Molecular Weight: 495.317
• Mol File: 882511-65-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(4-iodo-phenyl)-amine(CAS DataBase Reference)
• NIST Chemistry Reference: [6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(4-iodo-phenyl)-amine(882511-65-1)
• EPA Substance Registry System: [6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(4-iodo-phenyl)-amine(882511-65-1)

Safety Data

• Hazardous Substances Data: 882511-65-1(Hazardous Substances Data)

Upstream product

• 501684-22-6 methyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate 
• 476168-17-9 2-amino-4,5-bis-(2-methoxyethoxy)-benzoic acid methyl ester 
• 179688-14-3 methyl 3,4-bis{[2-(methyloxy)ethyl]oxy}benzoate 
• 2150-43-8 3,4-dihydroxybenzoic acid methyl ester 
• 99-50-3 3,4-Dihydroxybenzoic acid 
• 179688-29-0 6,7-bis-(2-methoxyethoxy)-4(3H)quinazolinone 
• 540-37-4 p-aminoiodobenzene 
• 183322-18-1 4-chloro-6,7-bis(2-methoxyethoxy)quinazoline 

Downstream Products

• 882511-69-5 [6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-[4-(3-dicyclohexylamino-prop-1-ynyl)-phenyl]-amine 

Relevant articles and documents

Synthesis and biological evaluation of allenic quinazolines using palladium-catalyzed hydride-transfer reaction

Allenic quinazolines 13a-h were designed as mimics of Tarceva, which is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, and synthesized from the corresponding 4-(iodoanilino)quinazolines or 4-(iodophenoxy)quinazolines with N,N-dicyclohexylprop-2-ynylamine by the Sonogashira coupling followed by palladium-catalyzed hydride-transfer reaction. Cell growth inhibition of 13a-h toward A431, Kato III, SKBR3, and HepG2 was examined. Among the compounds synthesized, 13a showed a similar cell growth inhibition to Tarceva. Moreover, 13d and 13h exhibited a specific growth inhibition toward Kato III cells (IC50 = 12 and 4.7 μM, respectively), although a significant inhibition toward other three cell lines was not observed at a 100 μM concentration of compounds.