882518-07-2Relevant academic research and scientific papers
Fluorescent inhibitors for IspF, an enzyme in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy
Crane, Christine M.,Kaiser, Johannes,Ramsden, Nicola L.,Lauw, Susan,Rohdich, Felix,Eisenreich, Wolfgang,Hunter, William N.,Bacher, Adelbert,Diederich, Francois
, p. 1069 - 1074 (2007/10/03)
Designed inhibitors (like 1) of IspF, a key enzyme in the non-mevalonate pathway for terpene biosynthesis and a potential antimalarial target, were synthesized and evaluated. Since fluorescent probes were introduced in these ligands, their affinity toward
