88252-20-4

Basic information

• Product Name: 3-Pyridinecarboxylic acid, 1,4-dihydro-4-oxo-6-(2-phenylethenyl)-, (E)-
• CAS NO: 88252-20-4
• Molecular Formula: C14H11NO3
• Molecular Weight: 241.246
• Mol File: 88252-20-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarboxylic acid, 1,4-dihydro-4-oxo-6-(2-phenylethenyl)-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxylic acid, 1,4-dihydro-4-oxo-6-(2-phenylethenyl)-, (E)-(88252-20-4)
• EPA Substance Registry System: 3-Pyridinecarboxylic acid, 1,4-dihydro-4-oxo-6-(2-phenylethenyl)-, (E)-(88252-20-4)

Safety Data

• Hazardous Substances Data: 88252-20-4(Hazardous Substances Data)

Upstream product

• 88251-84-7 1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxylic acid, t-butyl ester 
• 100-52-7 benzaldehyde 
• 88252-30-6 5-(Imidazole-1-carbonyl)-2-methyl-1H-pyridin-4-one 
• 88252-05-5 6-(2-Hydroxy-2-phenyl-ethyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid tert-butyl ester 
• 33821-58-8 6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 

Downstream Products

• 87762-29-6 Ethyl 1,4-Dihydro-4-oxo-6-(2-phenylethenyl)-3-pyridine-carboxylate 

Relevant articles and documents

Functionalization of substituted 2(1H)- and 4(1H)-pyridones. III. The preparation of substituted 6-vinyl-1,2-dihydro-2-oxo- and 1,4-dihydro-4-oxo-3-pyridinecarboxylic acids through the chemistry of pyridone dianions

The synthesis of various substituted 6-vinyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acids from the dianions of 1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile and the corresponding 3-t-butyl ester is reported. The dianions were generated with LDA in THF at low temperature and reacted with various carbonyl substrates. Several conditions for the dehydration and hydrolysis of these adducts to the vinyl pyridone acids are discussed. Employing the conditions used for the 2-pyridone analogs, a series of substituted 6-vinyl-1,4-dihydro-4-oxo-3-pyridinecarboxylic acids was prepared through the new dianion of 1,4-dihydro-6-methyl-4-oxo-3-pyridinecarboxylic acid, t-butyl ester.