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N-(3-fluoro-4-methylphenyl)-4,6-dimethyl-1H-indole-2-carboxamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

883014-15-1

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883014-15-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 883014-15-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,3,0,1 and 4 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 883014-15:
(8*8)+(7*8)+(6*3)+(5*0)+(4*1)+(3*4)+(2*1)+(1*5)=161
161 % 10 = 1
So 883014-15-1 is a valid CAS Registry Number.

883014-15-1Downstream Products

883014-15-1Relevant articles and documents

INHIBITORS OF DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS

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Page/Page column 21; 23; 24, (2015/11/16)

The present invention provides novel indoleamide compounds for treating tuberculosis, including drug-resistant M-tuberculosis, compositions comprising the indoleamides and methods of using the indoleamides in conjunction with other biologically active agents for the treatment of tuberculosis in a subject in need thereof.

Preliminary structure - Activity relationships and biological evaluation of novel antitubercular indolecarboxamide derivatives against drug-susceptible and drug-resistant Mycobacterium tuberculosis strains

Onajole, Oluseye K.,Pieroni, Marco,Tipparaju, Suresh K.,Lun, Shichun,Stec, Jozef,Chen, Gang,Gunosewoyo, Hendra,Guo, Haidan,Ammerman, Nicole C.,Bishai, William R.,Kozikowski, Alan P.

, p. 4093 - 4103 (2013/06/27)

Tuberculosis (TB) remains one of the leading causes of mortality and morbidity worldwide, with approximately one-third of the world's population infected with latent TB. This is further aggravated by HIV coinfection and the emergence of multidrug- and extensively drug-resistant (MDR and XDR, respectively) TB; hence the quest for highly effective antitubercular drugs with novel modes of action is imperative. We report herein the discovery of an indole-2-carboxamide analogue, 3, as a highly potent antitubercular agent, and the subsequent chemical modifications aimed at establishing a preliminary body of structure-activity relationships (SARs). These efforts led to the identification of three molecules (12-14) possessing an exceptional activity in the low nanomolar range against actively replicating Mycobacterium tuberculosis, with minimum inhibitory concentration (MIC) values lower than those of the most prominent antitubercular agents currently in use. These compounds were also devoid of apparent toxicity to Vero cells. Importantly, compound 12 was found to be active against the tested XDR-TB strains and orally active in the serum inhibition titration assay.

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