883032-29-9Relevant academic research and scientific papers
KOH/DMSO: A basic suspension for transition metal-free Tandem synthesis of 2,3-dihydroquinazolin-4(1H)-ones
Dutta, Apurba,Damarla, Krishnaiah,Bordoloi, Ankur,Kumar, Arvind,Sarma, Diganta
, p. 1614 - 1619 (2019)
A novel protocol for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones from 2-aminobenzamides and aldehyde derivatives catalyzed by KOH/DMSO suspension has been developed. The present transition metal free methodology is operationally simple, scalable and varieties of 2,3-dihydroquinazolin-4(1H)-one derivatives were obtained in good to excellent yields in short reaction times.
Gemini basic ionic liquid as bi-functional catalyst for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones at room temperature
Dutta, Apurba,Damarla, Krishnaiah,Kumar, Arvind,Saikia, Prakash J.,Sarma, Diganta
, (2020/01/08)
A cascade synthesis of 2,3-dihydroquinazolin-4(1H)-ones has been developed from 2-aminobenzonitriles and carbonyl analogues using Gemini basic ionic liquid as green catalyst cum solvent at room temperature. Both aldehydes and ketones were condensed with 2-aminobenzonitriles affording good to excellent yields of products. Moreover, the ionic liquids can be reused up to 5th cycle without significant loss of catalytic activity.
Efficient and mild synthesis of 2-aryl-substituted 2,3-dihydroquinazolin- 4(1H)-ones catalyzed by NaHSO4
Liu, Xia,Hu, Da-Hua,Shen, Hong
experimental part, p. 1365 - 1367 (2012/08/07)
Sodium hydrogen sulfate efficiently catalyzed in the condensation of anthranilamide with aromatic aldehydes under room temperature to afford 2-aryl-2, 3-dihydroquinazolin-4(1H)-ones in good yields and high purity. This methodology offers significant improvements with regard to the yield of products, inexpensive reagents and green aspects by avoiding toxic catalysts.
