883097-33-4

Upstream product

• 1276553-18-4 4-cyano-3-iodo-5-(morpholin-4-yl)thiophene-2-carboxylic acid ethyl ester 
• 1184915-94-3 ethyl 3-(4-chlorophenyl)-4-cyano-5-(morpholin-4-yl)thiophene-2-carboxylate 
• 1679-18-1 4-Chlorophenylboronic acid 

Downstream Products

• 1335330-78-3 3-(4-chlorophenyl)-4-cyano-5-(morpholin-4-yl)thiophene-2-carboxamide 
• 1335330-84-1 (E)-3-(4-chlorophenyl)-4-cyano-N-((dimethylamino)methylene)-5-(morpholin-4-yl)thiophene-2-carboxamide 
• 1335330-79-4 4-(4-chlorophenyl)-2-(morpholin-4-yl)-5-(1H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile 

Relevant academic research and scientific papers

Highly selective and potent thiophenes as PI3K inhibitors with oral antitumor activity

Highly selective PI3K inhibitors with subnanomolar PI3Kα potency and greater than 7000-fold selectivity against mTOR kinase were discovered through structure-based drug design (SBDD). These tetra-substituted thiophenes were also demonstrated to have good

THIOPHENES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) INHIBITORS

This invention provides thiophene compounds of formula (I) : wherein R1, R2, R3, R4, n, p, and m are as described in the specification. The compounds are inhibitors of PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.