1335330-79-4Relevant academic research and scientific papers
Highly selective and potent thiophenes as PI3K inhibitors with oral antitumor activity
Liu, Kevin K.-C.,Zhu, Jinjiang,Smith, Graham L.,Yin, Min-Jean,Bailey, Simon,Chen, Jeffrey H.,Hu, Qiyue,Huang, Qinhua,Li, Chunze,Li, Qing J.,Marx, Matthew A.,Paderes, Genevieve,Richardson, Paul F.,Sach, Neal W.,Walls, Marlena,Wells, Peter A.,Zou, Aihua
, p. 809 - 813 (2011/12/16)
Highly selective PI3K inhibitors with subnanomolar PI3Kα potency and greater than 7000-fold selectivity against mTOR kinase were discovered through structure-based drug design (SBDD). These tetra-substituted thiophenes were also demonstrated to have good
