88312-64-5

Basic information

• Product Name: Methyl2-aMino-5-nitronicotinate
• Synonyms: Methyl2-aMino-5-nitronicotinate;2-aMino-3-(Methoxycarbonyl)-5-nitropyridine;Methyl 2-aMino-5-nitropyridine-3-carboxylate;2-aMino-5-nitronicotinic acid Methyl ester
• CAS NO: 88312-64-5
• Molecular Formula: C₇H₇N₃O₄
• Molecular Weight: 197.15
• Mol File: 88312-64-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: Methyl2-aMino-5-nitronicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl2-aMino-5-nitronicotinate(88312-64-5)
• EPA Substance Registry System: Methyl2-aMino-5-nitronicotinate(88312-64-5)

Safety Data

• Hazardous Substances Data: 88312-64-5(Hazardous Substances Data)

Usage

Uses

Methyl 2-amino-5-nitronicotinate is a useful chemical for the synthesis of polyfunctionalized benzo[d]thiazole and its aza analog thiazolo[5,4-b]pyridine.

Upstream product

• 14080-32-1 5-nitropyrimidine 
• 105-34-0 methyl 2-cyanoacetate 
• 14667-47-1 methyl 2-aminonicotinate 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 

Relevant articles and documents

Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease

Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. It is endemic in South and Central America and recently has been found in other parts of the world, due to migration of chronically infected patients. The current treatment for Chagas disease is not satisfactory, and there is a need for new treatments. In this work, we describe the optimization of a hit compound resulting from the phenotypic screen of a library of compounds against T. cruzi. The compound series was optimized to the level where it had satisfactory pharmacokinetics to allow an efficacy study in a mouse model of Chagas disease. We were able to demonstrate efficacy in this model, although further work is required to improve the potency and selectivity of this series.

Rational multistep synthesis of a novel polyfunctionalized benzo[d]thiazole and its thiazolo[5,4-b]pyridine analogue

Reliable synthetic routes were studied for an access to a novel polyfunctionalized 6-amino-2-cyanobenzo[d]thiazole-5-carboxylate ester (1) and its analogue 5-amino-2-cyanothiazolo[5,4-b]pyridine-6-carboxylate ester (2). Both compounds 1 and 2 are functionalized as molecular bricks for the synthesis of innovative molecular systems. Part of the chemistry performed in this study was achieved under microwave irradiation.

NOVEL ANTIFUNGAL AGENT COMPRISING HETEROCYCLIC COMPOUND

The present invention provides an antifungal agent represented by the formula: [wherein A1 represents a 3-pyridyl group which may have a substituent, a quinolyl group which may have a substituent, or the like; X1 represents a group represented by the formula -NH-C(=O)-, a group represented by the formula -C(=O)-NH-, or the like; E represents a furyl group, a thienyl group, a pyrrolyl group, a phenyl group, a pyridyl group, a tetrazolyl group, a thiazolyl group or a pyrazolyl group; with the proviso that A1 may have 1 to 3 substituents, and E has one or two substituents].