88323-93-7Relevant academic research and scientific papers
Mechanochemical synthesis of 5-acetylthiazole: A step toward green and sustainable chemistry
Al-Bogami, Abdullah S.,Saleh, Tamer S.,Al-Shareef, Adel H.
, p. 3605 - 3611 (2020/08/13)
Mechanochemical synthesis of 5-acetylthiazole derivatives by one-pot three-component procedure over Silica Sulfuric acid under solvent-free conditions, has been developed. The durability of the catalyst was tested. The environmentally benign protocol introduced herein characterized by no hazardous organic solvent used, recyclability of the catalyst up to five runs without loss of its catalytic activity and high yields of products that confirm the utilization of some green chemistry principles in the mentioned protocol.
Synthesis of 3-Hydroxy-2-(substituted thiazolyl)-4-thiazolidinones
Mane, R. A.,Ingle, D. B.
, p. 690 - 692 (2007/10/02)
5-Acetyl-2-alkyl/alkylamino-4-methylthiazoles (IIa) and 5-acetyl-4-methyl-2-(substituted sulphamylphenylamino)thiazoles (IIb) have been synthesized by the interaction of 3-chloroacetylacetone with thioamides/alkylthiocarbamides (Ia) and substituted sulphamylphenylthiocarbamides (Ib), respectively.The acetyl derivatives (IIa-c) on treatment with hydroxylamine hydrochloride in pyridine yield the oxamino derivatives (III), which undergo condensation with thioglycolic acid (IV) in the presence of orthophosphoric acid in dry tetrahydrofuran to furnish the title compounds (V).
