88335-90-4

Upstream product

• 67-56-1 methanol 
• 35878-28-5 cyclopentane-cis-1,2-dicarboxylic acid anhydride 
• 1461-96-7 cis-1,2-cyclopentanedicarboxylic acid 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 80656-14-0 trans-1,2-cyclopentanedicarboxylic acid 

Downstream Products

• 1445590-56-6 (1,2-trans)-N-benzyl-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxamide 
• 1445589-44-5 methyl ((S)-1-((S)-2-(5-(4-(2-((1S,2S)-2-(3,3-dimethylmorpholine-4-carbonyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate 
• 1445589-43-4 methyl ((S)-3-methyl-1-((S)-2-(5-(4-(2-((1S,2S)-2-((R)-2-methylpiperidine-1-carbonyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)carbamate 
• 1445589-42-3 methyl ((S)-3-methyl-1-((S)-2-(5-(4-(2-((1S,2S)-2-((S)-2-methylpiperidine-1-carbonyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)carbamate 
• 1445589-35-4 methyl ((S)-3-methyl-1-((S)-2-(5-(4-(2-((1R,2R)-2-((S)-2-methylpyrrolidine-1-carbonyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)carbamate 
• 1445590-90-8 ((1R,2R)-2-(5-(4-bromophenyl)-4-chloro-1H-imidazol-2-yl)cyclopentyl)((R)-3-methylmorpholino)methanone 
• 1445597-10-3 methyl ((S)-1-((2S,4S)-4-methoxy-2-(5-(4-(2-((1R,2R)-2-((R)-3-methylmorpholine-4-carbonyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate 
• 1445590-85-1 (1R,2R)-2-(5-(4’-(2-((2S,3aS,6aS)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)octahydrocyclopenta[b]pyrrol-2-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid 
• 1445590-78-2 (1R,2 R)-2-(5-(4'-(2-((S)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid 
• 1445591-94-5 (1R,2R)-tert-butyl 2-(5-(4'-(2-((S)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-[1,1’-biphenyl]-4-yl)-1H-imidazol-2-yl)cyclopentanecarboxylate 
• 1445591-93-4 (1R,2R)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylate 

Relevant academic research and scientific papers

Practical and Highly Enantioselective Ring Opening of Cyclic Meso-Anhydrides Mediated by Cinchona Alkaloids

The cinchona alkaloid-mediated opening of prochiral cyclic anhydrides in the presence of methanol leading to optically active hemiesters is described. Very structurally diverse anhydrides are converted into their corresponding methyl monoesters, and either enantiomer can be obtained with up to 99% ee by using quinine or quinidine as directing additive. After the reaction, the alkaloids can be recovered almost quantitatively and reused without loss of enantioselectivity. Additionally, a catalytic protocol which permits the substoichiometric use of quinidine in the presence of easily accessible pentamethylpiperidine (pempidine) is presented.

NOVEL HEPATITIS C VIRUS INHIBITORS

The invention provides compounds of formula (I): wherein Rings A and A' are independently 5-membered optionally substituted aromatic heterocycles; Q is C(=O)NR1R1' or formula U is C(R4)2, O, S, S(=O)2, C(R4)2C(R4)2, CH2O, OCH2, CH2S, SCH2, CH2S(=O)2, S(=O)CH2 or C=C(Ru )2; X is CH2, CHR12, CR12R12, O, S, S(=O)2 or NRx; m is 0, 1, 2 or 3; n is 0, 1, 2 or 3; the other variables are as defined in the claims, which are of use in the treatment or prophylaxis of hepatitis C virus infection, and related aspects.