883718-60-3Relevant academic research and scientific papers
An efficient total synthesis of a sphingosine-1-phosphate receptor agonist KRP-203
Chino, Masao,Kiuchi, Masatoshi,Adachi, Kunitomo
, p. 3859 - 3866 (2008/09/21)
An efficient total synthesis of the S1P1 agonist, KRP-203, is described. The key step involves the conjugate addition of diethyl acetamidomalonate to a styrene compound to give the core structure of KRP-203. Multigram quantities of the targeted KRP-203, sufficient for several biological studies, were obtained in six steps with an overall yield of 58%.
PROCESS FOR PRODUCING 2-AMINO-2-[2-[4-(3-BENZYLOXY-PHENYLTHIO)-2-CHLOROPHENYL[ETHYL]-1,3-PROPANEDIOL HYDROCHLORIDE OR HYDRATE THEREOF AND INTERMEDIATE FOR THE SAME
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Page/Page column 5; 6, (2008/06/13)
A process for the industrial production of 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol hydrochloride (Compound I), an effective immunosuppressant. The process for producing 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chloro
AMINO ALCOHOL DERIVATIVE, ADDITION SALT THEREOF, AND IMMUNOSUPPRESSANT
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Page/Page column 34, (2008/06/13)
An amino alcohol derivative represented by the following general formula (1) (for example, (±)-2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-methylpentane-1-ol) exhibits strong immunosuppressive effect while causing less side effects:
