88382-46-1Relevant academic research and scientific papers
Design, synthesis and biological evaluation of novel hydroxamates and 2-aminobenzamides as potent histone deacetylase inhibitors and antitumor agents
Xie, Rui,Yao, Yue,Tang, Pingwah,Chen, Guangyao,Liu, Xia,Yun, Fan,Cheng, Chunhui,Wu, Xinying,Yuan, Qipeng
, p. 1 - 12 (2017/04/11)
Many studies have indicated that histone deacetylase (HDAC) inhibitors are promising agents for the treatment of cancer. With the aim to search for novel potent HDAC inhibitors, we designed and synthesized two series of hydroxamates and 2-aminobenzamides
Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents
Manos-Turvey, Alexandra,Watson, Emma E.,Sykes, Melissa L.,Jones, Amy J.,Baell, Jonathan B.,Kaiser, Marcel,Avery, Vicky M.,Payne, Richard J.
, p. 403 - 406 (2015/03/18)
The synthesis and anti-trypanosomal activity of a compound library based on a phenoxymethylbenzamide hit discovered in a high throughput screen is described. Several of the analogues exhibited potent activity against Trypanosoma brucei rhodesiense, a human infective strain of the trypanosome parasite, that serve as lead compounds for further optimisation. This journal is
