88393-10-6Relevant articles and documents
Synthesis and antifolate properties of 10-alkyl-8,10-dideazaminopterins
DeGraw,Christie,Brown,Kelly,Kisliuk,Gaumont,Sirotnak
, p. 376 - 380 (2007/10/02)
The synthesis of 10-alkyl analogues of the potent antitumor agent 8,10-dideazaminopterin is described. Alkylation of appropriate α-alkyl homoterephthalate esters with 2,4-diamino-6-(bromomethyl)-8-deazapteridine afforded 10-alkyl-10-carboxy-4-amino-4-deox