59584-27-9Relevant academic research and scientific papers
Transformation of carbonates into sulfones at the benzylic position via palladium-catalyzed benzylic substitution
Kuwano, Ryoichi,Kondo, Yutaka,Shirahama, Tsuyoshi
, p. 2973 - 2975 (2007/10/03)
(Chemical Equation Presented) The nucleophilic substitution of benzylic carbonates with sodium arenesulfinates was catalyzed by the palladium complex generated in situ from [Pd(η3-C3H5)Cl] 2 and DPEphos [bis(2-diphenylphosphinophenyl)ether]. The catalytic reaction proceeded in DMSO at 80°C and gave a variety of benzylic sulfones in high yields.
α,β-UNSATURATED HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS
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Page/Page column 21-22, (2008/06/13)
Disclosed are agents that inhibit histone deacetylase. More specifically, the present invention relates to novel hydroxamic acid derivatives or pharmaceutically acceptable salts thereof for anticancer agents or other therapeutic agents based on their histone deacetylase inhibitory activity.
Synthesis and Spetral Studies of Some Alkyl benzoate Derivatives. 3.
El-Bardan, Ali A.,Hamed, Ezzat A.,Saad, Esmat F.
, p. 133 - 134 (2007/10/02)
The synthesis, IR spectra, and proton NMR spectra of some alkyl benzoate derivatives are reported.
Correlation of Carbon-13 Substituent-Induced Chemical Shifts: meta- and para-Substituted Methyl Benzoates
Budesinsky, Milos,Exner, Otto
, p. 585 - 591 (2007/10/02)
Carbon-13 NMR spectra are reported for 69 substituted methyl benzoates in deuteriochloroform or in its mixture with dimethyl sulphoxide-d6.The substituent-induced chemical shifts (SCS) of the CO carbon correlate poorly with dual substituent parameters (DSP) in all possible modifications, and for meta derivatives in particular this correlation is both overparameterized and imprecise.A much better correlation was obtained with parameters (designated Bm, Bp and Cp) derived previously by principal component analysis (PCA) from a larger set.The SCS of the CH3 carbon correlate very well with the original simple Hammett equation, and no DSP treatment is needed.The clustering of substituents is not consequential in such a large set.KEY WORDS Methyl benzoates 13C NMR Substituent effects
Synthesis and antifolate properties of 10-alkyl-8,10-dideazaminopterins
DeGraw,Christie,Brown,Kelly,Kisliuk,Gaumont,Sirotnak
, p. 376 - 380 (2007/10/02)
The synthesis of 10-alkyl analogues of the potent antitumor agent 8,10-dideazaminopterin is described. Alkylation of appropriate α-alkyl homoterephthalate esters with 2,4-diamino-6-(bromomethyl)-8-deazapteridine afforded 10-alkyl-10-carboxy-4-amino-4-deox
