88416-58-4Relevant academic research and scientific papers
Photo- and radiation-chemical production of radical cations of methylbenzenes and benzyl alcohols and their reactivity in aqueous solution
Russo-Caia, Claudia,Steenken, Steen
, p. 1478 - 1485 (2002)
Radical cations of methylated benzenes and benzyl alcohols were generated by photoionization and by reaction SO4·- in aqueous solution. The photoionization requires two 248 nm photons. The lifetimes with the oxidant SO4 and absorption spectra of the radical cations produced were determined by time-resolved conductance and optical detection, and the reaction products were measured by GC. As expected, the radical cation lifetimes increase strongly with increasing number of additional methyl groups, and so does the ratio of deprotonation from a methyl or hydroxymethyl group vs. addition (of water) to a ring position. In the case of toluene the radical cation appears to have a chemical lifetime τ of 10-100 ps ≤ τ ≤ 20 ns, i.e., longer than it takes for an ion pair to separate into the free (solvated) ions, and it reacts predominantly by addition of water to the ring rather than by deprotonation from the methyl group. A further observation is that, as compared to methoxylated analogues, the methylated benzyl alcohol radical cations are much more reactive, such that OH-induction of side-chain fragmentation, as often required with methoxylated benzyl alcohol-type radical cations, is not necessary.
Chemoselective layer-by-layer approach utilizing click reactions with ethynylcyclooctynes and diazides
Münster, Niels,Nikodemiak, Paul,Koert, Ulrich
, p. 4296 - 4299 (2016)
Ethynylcyclooctynes and diazides were synthesized and applied for a chemoselective sequence of copper(I)-catalyzed azide-alkyne cycloadditions and strain-promoted azide-alkyne cycloadditions. Chemoselectivity within the reaction sequence was achieved by balancing three factors: Cu-catalysis/ring strain/steric shielding. A cholic acid derived triazide was subjected to the cycloaddition sequence as a model system for a layer-by-layer synthesis on surfaces.
HETEROAROMATIC COMPOUNDS AND USES THEREOF
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, (2022/04/03)
Providing heteraromatic compounds and uses thereof. In particular, providing heteraromatic compounds of formula (I), pharmaceutical compositions comprising same, methods for preparing same and uses thereof, wherein the variables are as defined in the description.
Interrupting the Barton?McCombie reaction: Aqueous deoxygenative trifluoromethylation of o-alkyl thiocarbonates
Liu, Zhi-Yun,Cook, Silas P.
supporting information, p. 808 - 813 (2021/02/01)
The site-selective trifluoromethylation of aliphatic systems remains an important challenge. This work describes a light-driven, copper-mediated trifluoromethylation of O-alkyl thiocarbonates. The reaction provides broad functional group tolerance (e.g., alkyne, alkene, phenol, free alcohol, electron-rich and -deficient arenes), thereby offering orthogonality and practicality for trifluoromethylation. A radical organometallic mechanism is proposed.
INHIBITORS OF JANUS KINASES
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Page/Page column 42, (2010/04/03)
The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3, TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
SYNTHESIS OF ARYLALKYL PEROXIDES WITH A PRIMARY HYDROXYL GROUP
Gevus', O. I.,Dikii, M. A.,Puchin, V. A.
, p. 1892 - 1894 (2007/10/02)
Monoperoxides and diperoxides with a primary hydroxyl group were synthesized from 1-(1-methyl-1-hydroxyethyl)-4-hydroxymethylbenzene and tert-butyl and isopropylbenzene hydroperoxides and 1,4-diisopropylbenzene hydroperoxides.The structure of the products
