81036-81-9

Basic information

• Product Name: Benzaldehyde, 4-(1-hydroxy-1-methylethyl)-
• CAS NO: 81036-81-9
• Molecular Formula: C10H12O2
• Molecular Weight: 164.204
• Mol File: 81036-81-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 4-(1-hydroxy-1-methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 4-(1-hydroxy-1-methylethyl)-(81036-81-9)
• EPA Substance Registry System: Benzaldehyde, 4-(1-hydroxy-1-methylethyl)-(81036-81-9)

Safety Data

• Hazardous Substances Data: 81036-81-9(Hazardous Substances Data)

Upstream product

• 99-87-6 4-methylisopropylbenzene 
• 24856-58-4 1,1-dimethoxy-1-(4-bromophenyl)methane 
• 3457-45-2 p-formylacetophenone 
• 75-16-1 methylmagnesium bromide 
• 1571-08-0 methyl 4-formylbenzoate 
• 917-54-4 methyllithium 
• 88416-58-4 1-(1-methyl-1-hydroxyethyl)-4-hydroxymethylbenzene 
• 1144509-57-8 2-(4-(2,2-diphenylcyclopropyl)phenyl)-2-propanol 
• 676-58-4 methylmagnesium chloride 
• 106-51-4 p-benzoquinone 
• 142581-73-5 4-(2-hydroxy-2-propyl)benzaldehyde dimethyl acetal 

Downstream Products

• 1206630-13-8 5-amino-2-[4-(1-hydroxy-1-methylethyl)phenyl]-1,3-thiazole-4-carboxamide 
• 142581-71-3 Trifluoro-acetic acid 1-{4-[(Z)-tert-butylimino-methyl]-phenyl}-1-methyl-ethyl ester 
• 142581-74-6 4-(2-hydroxy-2-propyl)benzaldehyde tert-butylimine 

Relevant articles and documents

COMPOUNDS FOR THE REDUCTION OF THE DELETERIOUS ACTIVITY OF EXTENDED NUCLEOTIDE REPEAT CONTAINING GENES

Aspects of the present disclosure include methods of reducing the deleterious impact of a target gene in a cell, such as the deleterious activity of a mutant extended nucleotide repeat (NR) containing target gene in a cell by contacting the cell with an effective amount of a tetrahydrocarbazole compound. The deleterious activity (e.g., toxicity and/or dis-functionality of products encoded thereby) of a mutant extended NR containing target gene may be reduced, e.g., by reducing (and in some instances differentially, including selectively, reducing) the production or activity of toxic expression products (e.g., RNA or protein) encoded by the target gene. Kits and compositions for practicing the subject methods are also provided.

Control of transient aluminum-aminals for masking and unmasking reactive carbonyl groups

A new reagent, the dimethylaluminum N,O-dimethylhydroxylamine complex, is effective at masking reactive carbonyl groups in situ from nucleophilic addition. This reagent allows chemoselective addition of reducing reagents, Grignard reagents, organolithiums, Wittig reagents, and enolates into substrates with multiple carbonyl groups. Moreover, the trapped carbonyl group, a stable aminal, can be unmasked in situ for additional synthetic manipulations.

INHIBITORS OF JANUS KINASES

The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3, TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.