88425-33-6

Basic information

• Product Name: Benzenesulfonamide, N-[2-(3,4-dimethoxyphenyl)-1-(hydroxymethyl)-2-oxoethyl]-, (S)-
• CAS NO: 88425-33-6
• Molecular Formula: C17H19NO6S
• Molecular Weight: 365.407
• Mol File: 88425-33-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-[2-(3,4-dimethoxyphenyl)-1-(hydroxymethyl)-2-oxoethyl]-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-[2-(3,4-dimethoxyphenyl)-1-(hydroxymethyl)-2-oxoethyl]-, (S)-(88425-33-6)
• EPA Substance Registry System: Benzenesulfonamide, N-[2-(3,4-dimethoxyphenyl)-1-(hydroxymethyl)-2-oxoethyl]-, (S)-(88425-33-6)

Safety Data

• Hazardous Substances Data: 88425-33-6(Hazardous Substances Data)

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 2859-78-1 4-Bromoveratrole 
• 85828-29-1 3-hydroxy-2-[(phenylsulfonyl)amino]propanoic acid 

Downstream Products

• 88425-44-9 (R)-2-(N-(phenylsulfonyl)amino)-3-(3,4-dimethoxyphenyl)propionic acid 
• 5796-17-8 D-Dopa 
• 88425-39-2 (R)-2-(N-(phenylsulfonyl)amino)-1-hydroxy-3-(3,4-dimethoxyphenyl)propane 

Relevant articles and documents

alpha -AMINO ACIDS AS CHIRAL EDUCTS FOR ASYMMETRIC PRODUCTS. A GENERAL SYNTHESIS OF D- alpha -AMINO ACIDS FROM L-SERINE.

A short and chirally efficient synthesis of four D- alpha -amino acids is described with L-serine as the chiral educt. The key C-C bond-forming reactions are the aminoacylations of organometallics with the lithium salt of N-(phenylsulfonyl)-L-serine (2) to give optically pure N-blocked alpha -amino ketones. Reduction of the carbonyl group to carbinol or methylene followed by oxidation of the hydroxymethyl to carboxyl gives the N-blocked D-amino acids. The examples investigated (norleucine, alpha -aminopimelic acid, DOPA, and allothreonine) demonstrate the broad applicability of the method.