884345-52-2Relevant academic research and scientific papers
Some limitations of an approach to the assembly of bryostatins by ring-closing metathesis
Dumeunier, Rapha?l,Gregson, Thomas,MacCormick, Somhairle,Omori, Hiroki,Thomas, Eric J.
, p. 2768 - 2783 (2017/04/04)
Preliminary studies into the use of ring-closing metathesis (RCM) in a convergent approach for the total synthesis of bryostatins are described. An ester that would have provided an advanced intermediate for a synthesis of a 20-deoxybryostatin by a RCM wa
Stereoselective formal synthesis of aspergillide A
Sabitha, Gowravaram,Vasudeva Reddy,Senkara Rao,Yadav
scheme or table, p. 4195 - 4198 (2010/09/12)
The stereoselective formal synthesis of aspergillide A (1), a cytotoxic 14-membered macrolide, is disclosed. The key intermediate, a trisubstituted tetrahydropyran core is prepared by SmI2-induced intramolecular reductive cyclization as well as
A preliminary evaluation of a metathesis approach to bryostatins
Ball, Matthew,Bradshaw, Benjamin J.,Dumeunier, Rapha?l,Gregson, Thomas J.,MacCormick, Somhairle,Omori, Hiroki,Thomas, Eric J.
, p. 2223 - 2227 (2007/10/03)
Preliminary investigations into the synthesis of bryostatins using ring-closing metathesis to form the C(16)-C(17) double bond led to a synthesis of the bryostatin analogue 51; precursors 26 and 52, which possess the geminal dimethyl group at C-18, did no
