884487-63-2

Upstream product

• 1514-82-5 2-bromo-3,3,3-trifluoropropene 
• 80910-01-6 (R)-2-(((4-methoxybenzyl)oxy)methyl)oxirane 
• 80910-01-6 (S)-2-[(4-methoxybenzyloxy)methyl]oxirane 

Downstream Products

• 916843-46-4 (S)-N-[1-(4-methoxybenzyloxy)-4-(trifluoromethyl)pent-4-en-2-yl]-4-methylbenzenesulfonamide 
• 916843-50-0 (S)-4-difluoromethylene-2-[(4-methoxybenzyloxy)methyl]-1-(4-methylbenzenesulfonyl)pyrrolidine 
• 916843-52-2 (S)-4-difluoromethylene-2-hydroxymethyl-1-(4-methylbenzenesulfonyl)pyrrolidine 
• 916843-43-1 (S)-allyl N-[1-(4-methoxybenzyloxy)-4-(trifluoromethyl)pent-4-en-2-yl]-N-(4-methylbenzenesulfonyl)carbamate 

Relevant academic research and scientific papers

1-(Trifluoromethyl)vinylation via oxirane or oxetane ring-opening: A facile synthesis of 4- or 5-hydroxy-functionalized 2-trifluoromethyl-1-alkenes

Introduction of a 1-(trifluoromethyl)vinyl group has been accomplished by the reaction of thermally unstable 1-(trifluoromethyl)vinyllithium (1) with strained cyclic ethers. Treatment of 2-bromo-3,3,3-trifluoropropene with butyllithium generates 1, which in turn reacts with several oxiranes or an oxetane at -100 °C in the presence of BF3·OEt2 to afford the corresponding 2-trifluoromethyl-1-alkenes bearing a hydroxy group on the 4- or 5-position. An enantiopure oxirane undergoes ring-opening without racemization, providing an optically active homoallyllic alcohol with a 3-trifluoromethyl group. Georg Thieme Verlag Stuttgart.

Divergent chemical synthesis of prolines bearing fluorinated one-carbon units at the 4-position via nucleophilic 5-endo-trig cyclizations

N-[3-(Trifluoromethyl)homoallyl]sulfonamides, prepared via ring opening of (5)-glycidyl ethers or 2-aryloxiranes with 1-(trifluoromethyl)vinyllithium, underwent intramolecular addition or SN2′-type reaction in the normally disfavored 5-endo-tri