884497-15-8Relevant academic research and scientific papers
Copper-Catalyzed Enantioselective Reductive Aldol Reaction of α,β-Unsaturated Carboxylic Acids to Alkyl Aryl Ketones: Silanes as Activator and Transient Protecting Group
Suzuki, Hirotsugu,Yoneoka, Kenji,Kondo, Sora,Matsuda, Takanori
supporting information, (2022/01/26)
The first enantioselective reductive aldol reaction of unprotected α,β-unsaturated carboxylic acids was developed by employing a copper/bisphosphine catalyst. The reaction features in situ protection and activation of an α,β-unsaturated carboxylic acid by a hydrosilane. The copper enolate formed in situ reacts with an alkyl aryl ketone to afford the β-hydroxy carboxylic acid with excellent enantioselectivity (up to 99 % ee). The corresponding gram-scale reaction with a low catalyst loading and the derivatization of the β-hydroxy carboxylic acids highlight the practicality of this transformation.
Copper-ClickFerrophos-complex-catalyzed enantioselective reductive aldol reaction
Kato, Minoru,Oki, Hiroshi,Ogata, Kenichi,Fukuzawa, Shin-Ichi
experimental part, p. 1299 - 1302 (2009/12/03)
We have prepared several ClickFerrophos families and tested for the Cu(I)-catalyzed asymmetric reductive aldol reaction of ketones and aldehydes with an acrylic ester in the presence of phenylsilane. The Cu(I)-ClickFerrophos complex is efficient for the r
