884659-56-7Relevant academic research and scientific papers
Novel modified chiral NiII complexes with the Schiff bases of (E)- and (Z)-2-aminobut-2-enoic acids: Synthesis and study
Saghiyan,Manasyan,Dadayan,Petrosyan,Petrosyan,Maleev,Khrustalev
, p. 442 - 450 (2006)
NiII complexes with the Schiff bases of (E)-and (Z)-2-aminobut-2-enoic acids were obtained with (S)-N-(2-benzoylphenyl)-1-(2- chlorobenzyl)pyrrolidine-2-carboxamide and (S)-N-(2-benzoylphenyl)-1-(3,4- dimethylbenzyl)pyrrolidine-2-carboxamide as
Synthesis of novel chiral NiII complexes of dehydroalanine Schiff bases and their reactivity in asymmetric nucleophilic addition reactions. Novel synthesis of (S)-2-carboxypiperazine
Saghiyan, Ashot S.,Stepanyan, Lala A.,Manasyan, Luiza L.,Geolchanyan, Arpine V.,Djamgaryan, Silva M.,Ajvazyan, Hrant R.,Panosyan, Henry A.,Maleev, Viktor I.,Saveleva, Tatiana F.
scheme or table, p. 2638 - 2645 (2011/02/16)
New chiral NiII complexes of Schiff bases of dehydroalanine with modified chiral auxiliaries (S)-2-N-[N′-(3,4-dichlorobenzyl)prolyl] aminobenzophenone (3,4-DCBPB), (S)-2-N-[N′-(3,4-dimethylbenzyl)prolyl] aminobenzophenone (3,4-DMBPB), (S)-2-N-[N′-(2-chlorobenzyl)prolyl] aminobenzophenone (2-CBPB), and (S)-2-N-[N′-(2-fluorobenzyl)prolyl]- aminobenzophenone (2-FBPB) have been synthesized. Asymmetric Michael addition reactions of primary and secondary amines and thiols to the dehydroalanine moieties of the complexes were studied. (S)-2-FBPB was found to be the best chiral auxiliary in terms of both selectivity of the reactions (de ～92-96%) and reactivity of the complexes. A novel synthetic route toward (S)-2-carboxypiperazine was developed based on the auxiliary.
