(S)-N-(2-benzoylphenyl)-1-(2-chlorobenzyl)pyrrolidine-2-carboxamide hydrochloride

Base Information

• Chemical Name: (S)-N-(2-benzoylphenyl)-1-(2-chlorobenzyl)pyrrolidine-2-carboxamide hydrochloride
• CAS No.: 884659-56-7
• Molecular Formula: C₂₅H₂₄ClN₂O₂*Cl
• Molecular Weight: 455.384
• Mol file: 884659-56-7.mol

Synonyms:(S)-N-(2-benzoylphenyl)-1-(2-chlorobenzyl)pyrrolidine-2-carboxamide hydrochloride

Chemical Property of (S)-N-(2-benzoylphenyl)-1-(2-chlorobenzyl)pyrrolidine-2-carboxamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(2-benzoylphenyl)-1-(2-chlorobenzyl)pyrrolidine-2-carboxamide hydrochloride

There total 8 articles about (S)-N-(2-benzoylphenyl)-1-(2-chlorobenzyl)pyrrolidine-2-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(S)-1-(2-Chloro-benzyl)-pyrrolidine-2-carboxylic acid; hydrochloride + (2-aminophenyl)(phenyl)methanone (2835-77-0) → (S)-N-(2-benzoylphenyl)-1-(2-chlorobenzyl)pyrrolidine-2-carboxamide hydrochloride (884659-56-7)

Guidance literature:

With phosphorus pentachloride; In dichloromethane; at 20 ℃; for 15h;

DOI:10.1007/s11172-006-0276-1

Reference yield:

1H-imidazole (288-32-4) + C28H26ClN3NiO4 → (S)-N-(2-benzoylphenyl)-1-(2-chlorobenzyl)pyrrolidine-2-carboxamide hydrochloride (884659-56-7) + (S)-2-amino-3-(1H-imidazol-1-yl)propionic acid (114717-14-5,68068-70-2)

Guidance literature:

C₂₈H₂₆ClN₃NiO₄; With acetic anhydride; sodium carbonate; In acetonitrile; at 25 - 70 ℃;

1H-imidazole; With sodium hydroxide; In acetonitrile; at 50 ℃; for 1.83333h;

With hydrogenchloride; water; In ethanol;

DOI:10.1016/j.tetasy.2010.10.015

Reference yield:

C28H26ClN3NiO4 + methylamine hydrochloride (593-51-1) → (S)-N-(2-benzoylphenyl)-1-(2-chlorobenzyl)pyrrolidine-2-carboxamide hydrochloride (884659-56-7) + (S)-2-amino-3-(methylamino)propionic acid hydrochloride (16012-55-8)

Guidance literature:

C₂₈H₂₆ClN₃NiO₄; With acetic anhydride; sodium carbonate; In acetonitrile; at 25 - 70 ℃;

methylamine hydrochloride; With potassium carbonate; In acetonitrile; at 50 ℃; for 1.5h;

With hydrogenchloride; water; In ethanol;

DOI:10.1016/j.tetasy.2010.10.015

upstream raw materials:

(2-aminophenyl)(phenyl)methanone

1H-imidazole

methylamine hydrochloride

ethanolamine