88466-70-0Relevant academic research and scientific papers
Reductive Knoevenagel Condensation with the Zn-AcOH System
Ivanov, Konstantin L.,Melnikov, Mikhail Ya.,Budynina, Ekaterina M.
, p. 1285 - 1291 (2020/11/13)
An efficient gram-scale one-pot approach to 2-substituted malonates and related structures is developed, starting from commercially available aldehydes and active methylene compounds. The technique combines Knoevenagel condensation with the reduction of the C=C bond in the resulting activated alkenes with the Zn-AcOH system. The relative ease with which the C=C bond reduction occurs can be traced to the accepting abilities of the substituents in the intermediate arylidene malonates.
Heterocyclic Ring and Carbocyclic Derivative
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Paragraph 0363-0364, (2016/02/18)
The present invention provides novel compounds having a P2X3 and/or P2X2/3 receptor antagonistic effect, e.g. a compound of Formula (I): wherein R2 is a hydrogen atom or the like; ring A is five- to seven-cycloalkane or th
A Facile one-pot benzylation of sodium enolates using trifluoromethanesulfonic anhydride and diphenyl sulfoxide
Takuwa, Tomofumi,Minowa, Tomofumi,Fujisawa, Hidehiko,Mukaiyama, Teruaki
, p. 476 - 480 (2007/10/03)
A facile one-pot C-benzylation of various sodium enolates derived from methyl malonate, β-ketoesters, a β-cyanoester, a β-cyanosulfone, ketones and a carboxylic ester is reported. Reaction of alkoxydiphenylsulfonium salts formed by treating various benzyl alcohols with diphenyl sulfide bis(trifluoromethanesulfonate) (derived from trifluoromethanesulfonic anhydride and diphenyl sulfoxide) proceeded smoothly, and the corresponding C-benzylated products were afforded in good to high yields.
A facile one-pot benzylation of sodium enolates using trifluoromethansulfonic anhydride and diphenyl sulfoxide
Takuwa, Tomofumi,Onishi, Jim Yoshitaka,Matsuo, Jun-Ichi,Mukaiyama, Teruaki
, p. 8 - 9 (2007/10/03)
A facile one-pot C-benzylation reaction proceeded smoothly and in good yields by treating various sodium enolates and benzyl alcohol with in situ generated alkoxy diphenyl sulfonium salt derived from trifluoromethansulfonic anhydride and diphenyl sulfoxide.
Photochemical carbon-silicon bond forming reaction on electron-deficient alkenes by disilanes and polysilanes via photoinduced electron transfer
Mizuno, Kazuhiko,Nakanishi, Kazuhisa,Chosa, Jun-ichi,Otsuji, Yoshio
, p. 35 - 44 (2007/10/02)
The phenanthrene-sensitized photoreaction of electron-deficient alkenes with disilanes in acetonitrile gave silylated alkanes in high yields.The photosilylation occurred in a highly regioselective manner at the position β to the electron-withdrawing group
PHOTOSILYLATION OF ELECTRON-DEFICIENT ALKENES BY USE OF DISILANES VIA PHOTOINDUCED ELECTRON-TRANSFER
Mizuno, Kazuhiko,Nakanishi, Kazuhisa,Chosa, Jun-ichi,Nguyen, Tien,Otsuji, Yoshio
, p. 3689 - 3692 (2007/10/02)
The photosilylation on electron-deficient alkenes such as 1-aryl-2,2-dicyanoethenes occurred regioselectively at the β-position to the electron-withdrawing groups upon irradiation with disilanes and trisilane.
AN EASY SYNTHESIS OF MONOMETHYL MALONATE DERIVATIVES
Matoba, Katsuhide,Yamazaki, Takao
, p. 2955 - 2956 (2007/10/02)
Monomethyl malonates (IIIa-c and Va) were synthesized from Meldrum's acid (Ia) by treating with an excess of diazomethane in the corresponding alcohols and piperidine, respectively, in quantitative yields.In a similar manner, 5-p-chlorobenzyl Meldrum's acid (Ib) afforded the corresponding monomethyl malonate derivatives (IIIe, f, and Vb).The mechanism proposed for this reaction is described.KEYWORDS - Meldrum's acid; monomethyl malonate; half ester; ketene ester; 4,6-dioxo-1,3-dioxane
