88466-73-3

Basic information

• Product Name: 1,3-Piperidinedicarboxylic acid, 3-methyl 1-(phenylmethyl) ester, (S)-
• CAS NO: 88466-73-3
• Molecular Formula: C15H19NO4
• Molecular Weight: 277.32
• Mol File: 88466-73-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,3-Piperidinedicarboxylic acid, 3-methyl 1-(phenylmethyl) ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Piperidinedicarboxylic acid, 3-methyl 1-(phenylmethyl) ester, (S)-(88466-73-3)
• EPA Substance Registry System: 1,3-Piperidinedicarboxylic acid, 3-methyl 1-(phenylmethyl) ester, (S)-(88466-73-3)

Safety Data

• Hazardous Substances Data: 88466-73-3(Hazardous Substances Data)

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule of the compound.

Explanation

An enantiomer is a molecule that has the same molecular formula as another molecule but differs in the spatial arrangement of its atoms.

Explanation

The compound is used as a starting material or building block in the production of various pharmaceuticals and organic compounds.

Explanation

The compound exists in a solid state and has a white color.

Explanation

The molecular weight is the mass of one mole of the compound, which is the sum of the atomic weights of all the atoms in the molecule.

Explanation

The compound can dissolve in certain organic solvents, making it easier to work with in chemical reactions and synthesis processes.

Explanation

The compound is used in the pharmaceutical industry to produce various drugs, likely due to its ability to be used as an intermediate in the synthesis of these drugs.

Explanation

The compound is also used in research and development for the creation of new chemical compounds, potentially leading to the discovery of new drugs or other useful materials.

Enantiomer

1,3-piperidinedicarboxylic acid

Common use

Intermediate in the synthesis of pharmaceuticals and other organic compounds

Physical state

White solid

Molecular weight

247.28 g/mol

Solubility

Soluble in organic solvents such as ethanol and methanol

Pharmaceutical industry application

Production of drugs

Research and development

Synthesis of new chemical compounds

Upstream product

• 637337-43-0 (4R)-3-(5-bromo-1-oxopentyl)-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one 
• 94471-35-9 benzyl N-(methoxymethyl) carbamate 
• 67-56-1 methanol 
• 637337-59-8 (4R)-3-[(2S)-2-({[(benzyloxy)carbonyl]amino}methyl)-5-bromo-1-oxopentyl]-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one 
• 175694-36-7 (3R,5S)-Piperidine-1,3,5-tricarboxylic acid 1-benzyl ester 3-methyl ester 

Downstream Products

• 405061-52-1 N-Cbz-3-hydroxymethylpiperidine 
• 140695-84-7 tert-butyl (3S)-3-(hydroxymethyl)piperidine-1-carboxylate 
• 4606-65-9 (S)-(hydroxymethyl)piperidine 

Relevant articles and documents

Enantioselective preparation of 2-aminomethyl carboxylic acid derivatives: Solving the β2-amino acid problem with the chiral auxiliary 4-isopropyl-5,5-diphenyloxazolidin-2-one (DIOZ)

Multigram amounts of suitably protected β2-amino acids with 17 of the 20 proteinogenic side chains are prepared by diastereoselective reactions of Li, B, or Ti enolates of the corresponding 3-acyl-4-isopropyl-5,5-diphenyloxazolidin-2-ones (acyl-DIOZ; 1) with appropriate electrophiles (amidomethylation, hydroxyalkylation, (benzyloxycarbonyl)methylation) in yields of 55-90% and with diastereoselectivities of 80 to > 97% (Scheme). The primary products 2-8 thus obtained are converted to protected β2-amino acids by standard procedures (Table 1). Many of the DIOZ derivatives are highly crystalline compounds (31 X-ray crystal structures in Table 2). The chiral auxiliary DIOZ, readily prepared in either enantiomeric form, is recovered with high yield.