88474-31-1

Basic information

• Product Name: 4-chloro-6-methoxy-2-methylpyrimidin-5-amine
• Synonyms: 4-Chloro-6-methoxy-2-methyl-5-pyrimidinamine;5-Amino-4-chloro-6-methoxy-2-methylpyrimidine;5-Pyrimidinamine,4-chloro-6-methoxy-2-methyl-;4-chloro-6-methoxy-2-methylpyrimidin-5-amine;4-Chloro-6-methoxy-2-methyl-pyrimidin-5-ylamine
• CAS NO: 88474-31-1
• Molecular Formula: C₆H₈ClN₃O
• Molecular Weight: 173.60022
• Mol File: 88474-31-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 272℃
• Flash Point: 118℃
• Appearance: /
• Density: 1.331
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 4-chloro-6-methoxy-2-methylpyrimidin-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-6-methoxy-2-methylpyrimidin-5-amine(88474-31-1)
• EPA Substance Registry System: 4-chloro-6-methoxy-2-methylpyrimidin-5-amine(88474-31-1)

Safety Data

• Hazardous Substances Data: 88474-31-1(Hazardous Substances Data)

Usage

General Description

4-Chloro-6-methoxy-2-methylpyrimidin-5-amine is a chemical compound with the molecular formula C6H8ClN3O. It is a pyrimidine derivative with a chlorine atom at the 4th position, a methoxy group at the 6th position, and a methyl group at the 2nd position. It also contains an amine group at the 5th position of the pyrimidine ring. This chemical may have various uses in pharmaceuticals, agrochemicals, or as an intermediate in organic synthesis. Its specific properties and potential applications would depend on its exact chemical structure and characteristics.

Upstream product

• 60331-15-9 2-methyl-4-methoxy-5-nitro-6-chloro-pyrimidine 
• 13162-43-1 4,6-dichloro-2-methyl-5-nitropyrimidine 
• 39906-04-2 5-amino-4,6-dichloro-2-methylpyrimidine 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 

Downstream Products

• 53135-45-8 4-methoxy-2-methyl-pyrimidin-5-ylamine 
• 88474-33-3 4-methoxycarbonyl-5-chloro-1,2,3-triazole 
• 75438-57-2 moxonidine 
• 75438-58-3 4-chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride 
• 106882-70-6 N-acetyl-sulfanilic acid-(4-methoxy-2-methyl-pyrimidin-5-ylamide) 
• 7749-24-8 sulfanilic acid-(4-methoxy-2-methyl-pyrimidin-5-ylamide) 
• 461658-65-1 N-[4-chloro-6-methoxy-2-methylpyrimid-5-yl]-N'-benzoylthiourea 

Relevant articles and documents

Identification, synthesis and pharmacological activity of moxonidine metabolites

The metabolism of moxonidine, 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5- pyrimidinamine, LY326869, in rats, mice, dogs, and humans has been examined. At least 17 metabolites were identified or tentatively identified in the different species by HPLC, LC/MS and LC/MS/MS. The identities of seven of the major metabolites have been verified by independent synthesis. The metabolites are generally derived from oxidation and conjugation pathways. Oxidation occurred at the imidazolidine ring as well as the methyl at the 2 position of the pyrimidine ring. All seven metabolites were examined in the spontaneously hypertensive rats (3 mg kg-1, i.v.) for pressure and heart rate. Only one, 2-hydroxymethyl-4-chloro-5-(imidazolidin-2-ylidenimino)-6-methoxypyrimidine, exerted a short-lasting decrease in blood pressure, albeit attenuated in magnitude compared to moxonidine.