88474-31-1

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-6-methoxy-2-methylpyrimidin-5-amine is used as a pharmaceutical intermediate for the synthesis of various therapeutic agents. Its unique chemical structure allows for the development of drugs targeting specific biological pathways or receptors, potentially leading to novel treatments for a range of diseases.
Used in Agrochemical Industry:
In the agrochemical industry, 4-chloro-6-methoxy-2-methylpyrimidin-5-amine is used as a building block for the creation of new pesticides or herbicides. Its chemical properties can be tailored to target specific pests or weeds, offering more effective and environmentally friendly solutions for crop protection.
Used in Organic Synthesis:
4-Chloro-6-methoxy-2-methylpyrimidin-5-amine serves as a key intermediate in organic synthesis, enabling the production of a variety of complex organic compounds. Its presence in the molecular structure can influence the reactivity and selectivity of the synthesized compounds, making it a valuable component in the development of new materials and chemicals.

Upstream product

• 67-56-1 methanol 
• 39906-04-2 5-amino-4,6-dichloro-2-methylpyrimidine 
• 124-41-4 sodium methylate 
• 13162-43-1 4,6-dichloro-2-methyl-5-nitropyrimidine 
• 60331-15-9 2-methyl-4-methoxy-5-nitro-6-chloro-pyrimidine 

Downstream Products

• 53135-45-8 4-methoxy-2-methyl-pyrimidin-5-ylamine 
• 461658-65-1 N-[4-chloro-6-methoxy-2-methylpyrimid-5-yl]-N'-benzoylthiourea 
• 75438-57-2 moxonidine 
• 75438-58-3 4-chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride 
• 106882-70-6 N-acetyl-sulfanilic acid-(4-methoxy-2-methyl-pyrimidin-5-ylamide) 
• 7749-24-8 sulfanilic acid-(4-methoxy-2-methyl-pyrimidin-5-ylamide) 
• 88474-33-3 4-methoxycarbonyl-5-chloro-1,2,3-triazole 

Relevant academic research and scientific papers

Identification, synthesis and pharmacological activity of moxonidine metabolites

The metabolism of moxonidine, 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5- pyrimidinamine, LY326869, in rats, mice, dogs, and humans has been examined. At least 17 metabolites were identified or tentatively identified in the different species by HPLC, LC/MS and LC/MS/MS. The identities of seven of the major metabolites have been verified by independent synthesis. The metabolites are generally derived from oxidation and conjugation pathways. Oxidation occurred at the imidazolidine ring as well as the methyl at the 2 position of the pyrimidine ring. All seven metabolites were examined in the spontaneously hypertensive rats (3 mg kg-1, i.v.) for pressure and heart rate. Only one, 2-hydroxymethyl-4-chloro-5-(imidazolidin-2-ylidenimino)-6-methoxypyrimidine, exerted a short-lasting decrease in blood pressure, albeit attenuated in magnitude compared to moxonidine.

Synthesis of 4-Chloro-1,2,3-tiazole Derivatives by Diazotization of 6-Substituted 5-Amino-4-chloropyrimidines

It is shown that 4-cyano- and 4-carbalkoxy-5-chloro-1,2,3-triazoles, respectively, are formed in the diazotization of 4,6-dichloro- and 4-chloro-6-alkoxy-5-aminopyrimidines.It was observed that a methyl group in the 2 position of the starting pyrimidine derivative does not affect the structures of the reaction products under the described conditions.