88486-02-6

Basic information

• Product Name: (4-Hydroxy-phenyl)-phenylamino-acetonitrile
• Synonyms: (4-Hydroxy-phenyl)-phenylamino-acetonitrile;2-(4-hydroxyphenyl)-2-(phenylamino)acetonitrile
• CAS NO: 88486-02-6
• Molecular Formula: C₁₄H₁₂N₂O
• Molecular Weight: 224.25788
• Mol File: 88486-02-6.mol
• Article Data: 20

Chemical Properties

• Melting Point: 120-122 °C(Solv: ethanol (64-17-5))
• Boiling Point: 429.8±35.0 °C(Predicted)
• Appearance: /
• Density: 1 +-.0.06 g/cm3(Predicted)
• PKA: 9.36±0.26(Predicted)
• CAS DataBase Reference: (4-Hydroxy-phenyl)-phenylamino-acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Hydroxy-phenyl)-phenylamino-acetonitrile(88486-02-6)
• EPA Substance Registry System: (4-Hydroxy-phenyl)-phenylamino-acetonitrile(88486-02-6)

Safety Data

• Hazardous Substances Data: 88486-02-6(Hazardous Substances Data)

Usage

Description

(4-Hydroxy-phenyl)-phenylamino-acetonitrile, with the molecular formula C14H12N2O, is a nitrile compound characterized by the presence of a phenylamino group and a hydroxy-phenyl group. The phenylamino group is attached to the acetonitrile group, which gives this compound unique properties and potential applications in various fields.

Uses

Used in Organic Synthesis:
(4-Hydroxy-phenyl)-phenylamino-acetonitrile is used as an intermediate in the synthesis of various organic compounds. Its unique structure allows for further chemical reactions and modifications, making it a valuable building block in the creation of new molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (4-Hydroxy-phenyl)-phenylamino-acetonitrile is used as a precursor for the development of pharmaceuticals. Its structural features can be exploited to design and synthesize new drug candidates with potential therapeutic applications.
Used in Pharmaceutical Production:
(4-Hydroxy-phenyl)-phenylamino-acetonitrile is used as a key component in the production of certain pharmaceuticals. Its incorporation into drug molecules can contribute to their efficacy, safety, and other pharmacological properties.
Used in Research and Development:
(4-Hydroxy-phenyl)-phenylamino-acetonitrile is also utilized in research and development settings, where it can be studied to understand its properties, reactivity, and potential interactions with biological systems. This knowledge can then be applied to the design of new drugs and the improvement of existing ones.

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 123-08-0 4-hydroxy-benzaldehyde 
• 62-53-3 aniline 
• 1689-73-2 N-(p-hydroxybenzylidene)aniline 
• 151-50-8 potassium cyanide 

Relevant articles and documents

Catalytic Strecker reaction: g-C3N4-anchored sulfonic acid organocatalyst for the synthesis of α-aminonitriles

Abstract: Efficient organocatalyst for enantioselective Strecker reaction was synthesized using g-C3N4 sheets (CN). CN-anchored sulfonic acid (CN-Bu-SO3H) was found to be a highly efficient and recoverable organocatalyst f

Cu/Ni-doped sulfated zirconium oxide immobilized on CdFe2O4 NPs: a cheap, sustainable and magnetically recyclable inorgano-catalyst for the efficient preparation of α-aminonitriles in aqueous media

Abstract: A new multifunctional bimetallic nanocatalyst was prepared by immobilization of Cu/Ni-doped sulfated zirconium oxide on magnetic cadmium ferrite (CdFe2O4@SiO2@ZrO2/SO42?/Cu/Ni) and used as an efficient recyclable catalyst for one-pot as well as stepwise preparation of α-aminonitriles under mild conditions. The magnetic nanocatalyst was characterized by FTIR, TGA, VSM, XRD, EDX, FE-SEM, and TEM analyses. Also, the surface acidity of the catalyst was measured by pyridine adsorption assay. The catalyst possesses various active sites which could catalyst a variety of aromatic and aliphatic aldehydes to the corresponding α-amionitriles under moderate to high yields in the presence of aniline. Furthermore, transformation of ketones to the desired α-amionitriles and some bis-aminonitriles was also performed by this method. The catalyst could be readily recovered from the reaction mixture and reused for several times without significant loss of activity. Graphic abstract: A general and efficient method has been developed for transformation of a variety of aliphatic, aromatic aldehydes and ketones to the corresponding α-aminonitriles using a multifunctional recyclable CdFe2O4@SiO2@ZrO2/SO42?/Cu/Ni nanocatalyst.[Figure not available: see fulltext.]

Gallic acid grafted to amine-functionalized magnetic nanoparticles as a proficient catalyst for environmentally friendly synthesis of α-aminonitriles

An effective approach of one-pot catalytic Strecker reaction between aromatic aldehydes, aniline or toluidine and trimethylsilyl cyanide in the presence of amine-functionalized Fe3O4@SiO2 nanoparticles grafted with gallic