88491-44-5

Usage

Uses

Used in Pharmaceutical Research:
2-BROMO-4-HYDROXYPHENYLACETIC ACID is used as a building block for the development of new pharmaceutical compounds. Its unique structure allows for the creation of various biologically active molecules, making it a valuable asset in drug discovery and development.
Used in Organic Synthesis:
In the field of organic synthesis, 2-BROMO-4-HYDROXYPHENYLACETIC ACID is used as a key intermediate for the synthesis of complex organic molecules. Its presence in the molecular structure facilitates the formation of desired products through various chemical reactions.
Used in Antifungal and Antibacterial Applications:
2-BROMO-4-HYDROXYPHENYLACETIC ACID has been studied for its potential antifungal and antibacterial properties. It is used as an active ingredient in the development of new antimicrobial agents to combat resistant strains of bacteria and fungi.
Used in Treatment of Inflammatory and Neurodegenerative Diseases:
Due to its potential therapeutic effects, 2-BROMO-4-HYDROXYPHENYLACETIC ACID is being investigated for its use in the treatment of inflammatory and neurodegenerative diseases. Its ability to modulate immune responses and protect neurons makes it a promising candidate for further research and development.
Used as a Precursor in Synthesis of Biologically Active Compounds:
2-BROMO-4-HYDROXYPHENYLACETIC ACID is also used as a precursor in the synthesis of various biologically active compounds. Its presence in the molecular structure allows for the creation of new compounds with potential applications in medicine and other fields.

Upstream product

• 591-20-8 3-Bromophenol 
• 66916-99-2 2-(2-bromo-4-(methoxy)phenyl)acetic acid 

Downstream Products

• 134937-20-5 2-(3,5-dimethoxyphenyl)-6-hydroxybenzofuran 
• 56317-21-6 moracin M 

Relevant academic research and scientific papers

Copper-catalyzed intramolecular cross dehydrogenative coupling approach to coumestans from 2′-hydroxyl-3-arylcoumarins

A copper-catalyzed intramolecular cross dehydrogenative C-O coupling reaction of 2′-hydroxyl-3-arylcoumarins was developed. This protocol provided a facile and efficient strategy for the construction of natural coumestans and derivatives in moderate to high yields. This transformation exhibited good functional group compatibility and was amenable to substrates with free phenolic hydroxyl groups.

Preparation method of 2,4-dihydroxyphenyl acetic acid

The invention discloses a preparation method of 2,4-dihydroxyphenyl acetic acid, which comprises the following steps: by using m-bromophenol and glyoxalic acid as raw materials, carrying out condensation reaction and acidification to obtain hydroxy o-bromomandelic acid, reducing the hydroxy o-bromomandelic acid to obtain p-hydroxy o-bromophenyl acetic acid, carrying out bromine hydroxylation reaction on the p-hydroxy o-bromophenyl acetic acid in the presence of a catalyst under alkaline conditions, and carrying out acidification to obtain the 2,4-dihydroxyphenyl acetic acid. The method has the advantages of simple and accessible raw materials, simple reaction treatment and higher yield. The obtained intermediate also has important applications.

Synthesis of coumestrol and aureol

A total synthesis of coumestrol (1) and aureol (2) is described. The Perkin condensation of 2-bromo-4-hydroxylphenylacetic acid (6) and o-hydroxybenzaldehydes (7) gave the corresponding 2′-bromo-3-arylcoumarins (9). A copper-catalyzed consecutive hydroxylation and aerobic oxidative coupling of 9 under microwave conditions facilitated the total synthesis of 1 and 2, respectively, with spectroscopic data highly similar to those of natural products.

BICYCLIC COMPOUND

The present invention provides a compound having an ACC inhibitory action, which is useful as an agent for the prophylaxis or treatment of obesity, diabetes and the like, and having superior efficacy. The present invention relates to a compound represente