88491-44-5

Basic information

• Product Name: 2-BROMO-4-HYDROXYPHENYLACETIC ACID
• Synonyms: 2-Bromo-4-hydroxyphenylaceticacid
• CAS NO: 88491-44-5
• Molecular Formula: C₈H₇BrO₃
• Molecular Weight: 231.04
• Product Categories: Aromatic Phenylacetic Acids and Derivatives
• Mol File: 88491-44-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 394.6±27.0 °C(Predicted)
• Appearance: /
• Density: 1.757±0.06 g/cm3(Predicted)
• PKA: 4.26±0.10(Predicted)
• CAS DataBase Reference: 2-BROMO-4-HYDROXYPHENYLACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4-HYDROXYPHENYLACETIC ACID(88491-44-5)
• EPA Substance Registry System: 2-BROMO-4-HYDROXYPHENYLACETIC ACID(88491-44-5)

Safety Data

• Hazardous Substances Data: 88491-44-5(Hazardous Substances Data)

Usage

General Description

2-Bromo-4-hydroxyphenylacetic acid is a chemical compound with the molecular formula C8H7BrO3. It is a derivative of phenylacetic acid with a bromo and hydroxy group attached to the phenyl ring. 2-BROMO-4-HYDROXYPHENYLACETIC ACID is commonly used as a building block in organic synthesis and pharmaceutical research. It has been studied for its potential antifungal and antibacterial properties and its potential use in the treatment of inflammatory and neurodegenerative diseases. Additionally, it has been used as a precursor in the synthesis of various biologically active compounds. Overall, 2-bromo-4-hydroxyphenylacetic acid is a versatile chemical with potential applications in various fields, including medicine and drug development.

Upstream product

• 591-20-8 3-Bromophenol 
• 66916-99-2 2-(2-bromo-4-(methoxy)phenyl)acetic acid 

Downstream Products

• 1380068-72-3 cyclopropylmethyl [2-bromo-4-(cyclopropylmethoxy)phenyl]acetate 
• 1380070-11-0 2-(2-bromo-4-hydroxyphenyl)-N-methoxy-N-methylacetamide 
• 1380068-73-4 [2-bromo-4-(cyclopropylmethoxy)phenyl]acetic acid 
• 1380068-74-5 2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-N-methoxy-N-methylacetamide 
• 1380068-75-6 2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-1-(5-{[tris(1-methylethyl)silyl]oxy}pyridin-2-yl)ethanone 
• 1380068-76-7 2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-1-(5-{[tris(1-methylethyl)silyl]oxy}pyridin-2-yl)ethanol 
• 614-82-4 (2,4-dihydroxyphenyl)acetic acid 
• 479-13-0 coumestrol 
• 88478-03-9 aureol 

Relevant articles and documents

Copper-catalyzed intramolecular cross dehydrogenative coupling approach to coumestans from 2′-hydroxyl-3-arylcoumarins

A copper-catalyzed intramolecular cross dehydrogenative C-O coupling reaction of 2′-hydroxyl-3-arylcoumarins was developed. This protocol provided a facile and efficient strategy for the construction of natural coumestans and derivatives in moderate to high yields. This transformation exhibited good functional group compatibility and was amenable to substrates with free phenolic hydroxyl groups.

Synthesis of coumestrol and aureol

A total synthesis of coumestrol (1) and aureol (2) is described. The Perkin condensation of 2-bromo-4-hydroxylphenylacetic acid (6) and o-hydroxybenzaldehydes (7) gave the corresponding 2′-bromo-3-arylcoumarins (9). A copper-catalyzed consecutive hydroxylation and aerobic oxidative coupling of 9 under microwave conditions facilitated the total synthesis of 1 and 2, respectively, with spectroscopic data highly similar to those of natural products.