885-07-4

Upstream product

• 5343-99-7 1,2-naphthalenedicarboxylic anhydride 
• 593-51-1 methylamine hydrochloride 
• 37845-14-0 3,4-Dihydro-naphthalindicarbonsaeure-(1,2)-anhydrid 
• 74-89-5 methylamine 
• 100-42-5 styrene 
• 930-88-1 N-methylmaleimide 

Downstream Products

• 104228-24-2 2-methyl-4-phenyl-3,4-dihydro-1H-naphth<1,2-c>azepine-1,5(2H)-dione 
• 104228-28-6 4-methyl-2-phenyl-3,4-dihydro-1H-naphth<2,1-c>azepine-1,5(2H)-dione 
• 41976-80-1 (2-methoxyethane-1,1-diyl)dibenzene 
• 104228-25-3 4,4-diphenyl-2-methyl-3,4-dihydro-1H-naphth<1,2-c>azepine-1,5(2H)-dione 
• 104228-29-7 2,2-diphenyl-4-methyl-3,4-dihydro-1H-naphth<2,1-c>azepine-1,5(2H)-dione 

Relevant academic research and scientific papers

Spectroscopic Properties of Aromatic Dicarboximides. Part 1.-N-H and N-Methyl-substituted Naphthalimides

The photophysical properties of the N-H and N-methyl derivatives of 1,2-, 2,3- and 1,8-naphtalimides have been studied.The shift of the fluorescence emission position as a function of the solvent polarity indicates only a weak variation of dipole moment for the excited state compared with the corresponding value in the ground state (5.7 D for 2b, 2.8 D for 3b and f, increases.This difference is found to arise from the energy gap between the lowest 1(?,?*) singlet excited state and the upper 3(n,?*) triplet state, which is of the order of 9 kcal mol-1 for 2b and less than 2 kcal mol-1 for 4b in acetonitrile solution.Protic solvents increase the energy difference between the n,?* and ?,?* states thus decreasing the mixing of the two levels; as a consequence, the lifetime of 4b is increased, i.e. from 60 ps in hexane to 6.1 ns in trifluoroethanol.A triplet-triplet annihilation process occurs with the N-methyl derivatives 3b and 4b which leads to a monomer delayed fluorescence with the former, and mainly to a delayed excimer emission with the latter.

MOFs come up to scratch: An environmentally benign route to oxidative [4 + 2] cycloaddition on maleimides solely: Via MOFs in water

The first Diels-Alder reaction of vinyl arenes with ene systems catalyzed by MOFs is reported. Maleimides and maleic anhydride were annulated/dehydrogenated on styrenes in the presence of a mixed-metal (FeNi)MIL-88A catalyst. Neither an additional oxidant nor a source of halogen is needed to drive this oxidative [4 + 2] cyclization reaction. Kinetic evidence such as activation entropy corroborates the proposed concerted mechanism. The reaction proceeds merely through a cost-effective catalyst in water as the greenest solvent. The product of annulation of styrene with maleic anhydride was used for the first L-selective annulative π-extension on naphthalene.

C-H Activation under the Guise of Diels-Alder Reaction: Annulation toward the Synthesis of Benzo[e]isoindole-1,3-diones

A new paradigm in the coupling of external alkenes with internal electron-deficient alkenes has been investigated in which an unprecedented annulation of vinylarenes on maleimides takes place. The reaction is carried out via a tandem in situ activation of both olefinic and aromatic C-H bonds of styrenes driving the reaction in a pseudo-Diels-Alder mode.

Novel methods of synthesizing naphtho[1,2-c]furan-1,3-dione and benzo[e]isoindole-1,3-dione

Convenient methods of synthesizing naphtho[1,2-c]furan-1,3-dione and benzo[e]isoindole-1,3-dione from phenylbutyric acid derivatives have been established. Naphtho[1,2-c]furan-1,3-dione and benzo[e]isoindole-1,3-dione were obtained respectively from 4,5-d

Neurotrophin antagonist compositions

A pharmaceutical composition comprising a compound of Formula I 1wherein R1 is selected from, inter alia, alkyl, aryl-loweralkyl, heterocycle-loweralkyl, loweralkyl-carbonate; optionally substituted amino; benzimidaz-2-yl; optionally substituted phenyl; loweralkyl-(R5)(R6) wherein one of R5 and R6 is selected from H and and the other is selected from carboxy, carboxy-loweralkyl and loweralkoxycarbonyl; NHCH2CH2OX wherein X represents an in vivo hydrolyzable ester; and R2 and R3 are independently selected from H, NO2, halo, di(loweralkyl)amino, cyano, C(O)OH, phenyl-S—, loweralkyl, and Z(O)OR7 wherein Z is selected from C and S and R7 is selected from H, loweralkylamino and arylamino; or pharmaceutically acceptable salts or certain in vivo hydrolyzable esters or amides thereof, in an amount effective to inhibit neurotrophin-mediated activity, and a suitable carrier, is described. The compositions are useful to inhibit undesirable neurotrophin-mediated activity such as the neurite outgrowth that occurs in some neurodegenerative disease states.