885030-22-8Relevant articles and documents
Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: Discovery of MK-2918
Paone, Daniel V.,Nguyen, Diem N.,Shaw, Anthony W.,Burgey, Christopher S.,Potteiger, Craig M.,Deng, James Z.,Mosser, Scott D.,Salvatore, Christopher A.,Yu, Sean,Roller, Shane,Kane, Stefanie A.,Selnick, Harold G.,Vacca, Joseph P.,Williams, Theresa M.
, p. 2683 - 2686 (2011/06/20)
In our ongoing efforts to develop CGRP receptor antagonists for the treatment of migraine, we aimed to improve upon telecagepant by targeting a compound with a lower projected clinical dose. Imidazoazepanes were identified as potent caprolactam replacemen