885044-06-4

Upstream product

• 127099-85-8 N-Cyanoguanidine 
• 1004-00-8 4-chloro-2-aminobenzenethiol 
• 108-42-9 3-chloro-aniline 
• 4947-89-1 1-(3-chlorophenyl)-2-thiourea 
• 1391365-31-3 N₁,N₂-bis(tert-butyloxycarbonyl)-N₃-(5-chlorobenzothiazol-2-yl)guanidine 
• 1391365-04-0 N₁-(9H-fluoren-9-ylmethyloxycarbonyl)-N₂-(3-chlorophenyl)thiourea 
• 20358-00-3 2-amino-5-chlorobenzothiazole 

Relevant academic research and scientific papers

Discovery of benzothiazole guanidines as novel inhibitors of thrombin and trypsin IV

In a project to find novel neutral P1 fragments for the synthesis of thrombin inhibitors with improved pharmacokinetic properties, fragments containing a benzothiazole guanidine scaffold were identified as weak thrombin inhibitors. WaterLOGSY (Water-Ligan

Microwave-assisted synthesis of s-triazino[2,1-b][1,3]benzoxazoles, s-triazino[2,1-b][1,3]benzothiazoles, and s-triazino[1,2-a]benzimidazoles

2-Amino-4-oxo-derivatives of s-triazino[2,1e][1,3]benzoxazoles, s-triazino[2,1,b][1,3]benzothiazoles, and s-triazino[1,2-a]benzimidazoles were synthesized by carbonylation of 2-benz-oxazolylguanidines, 2- benzothiazolylguanidines, and 2-benzimidazolylguanidines with phenyl isocyanate under microwave irradiation (180°C, 15 minutes). Using phenyl isothiocyanate instead of phenyl isocyanate under the same conditions led to the successful ring closure via thiocarbonylation of 2-benzoxazolylguanidines. However, the formation of 2-imino-4-phenylimino-s-triazino[2,1-b][1,3]benzothiazoles from 2-benzothiazolylguanidines was observed instead under microwave irradiation conditions. Georg Thieme Verlag Stuttgart.