885133-35-7Relevant academic research and scientific papers
A simple method for the preparation of di-, tri- and tetrasubstituted non-symmetrical ureas
Bridgeman, Eve,Tomkinson, Nicholas C. O.
, p. 243 - 246 (2007/10/03)
The synthesis of a series of di-, tri- and tetrasubstituted non-symmetrical ureas is described. Di- and trisubstituted ureas are prepared in excellent yield by treatment of a phenyl carbamate in a self-tunable single-mode microwave synthesizer with a primary or secondary amine. The synthetically more challenging tetrasubstituted urea can be prepared using the 4-nitrophenyl carbamate and a secondary amine. Georg Thieme Verlag Stuttgart.
