885208-06-0Relevant articles and documents
Photoinitiated release of an aziridinium ion precursor for the temporally controlled alkylation of nucleophiles
McCarron, Stephen T.,Feliciano, Mariel,Johnson, Jeffreys N.,Chambers, James J.
, p. 2395 - 2398 (2013)
A photo-activatable aziridinium precursor has been developed to investigate the possibility of a photo-initiated traditional nucleophilic reaction. The photolysis of a quaternary amine yields a tertiary amine and has allowed us to temporally control aziridinium formation and subsequent alkylation of a colorimetric nucleophilic reporter molecule. We have also used this photo-initiated reaction to alkylate a sulfhydryl group. This new photo-initiated alkylation strategy is water-soluble and expands the toolkit of photo-activated crosslinkers for protein labeling research.
